Update README.md

README.md

 # Squadrito_LiverTumor2022_Spatial
 
+Kerzel T, Giacca G, Beretta S, Scotti MG, et al.
+**Targeted Interferon Delivery Through In Vivo Engineered Macrophages Eradicates Liver Metastases.**
+2022.
+
+GEO: [GSE221359](https://www.ncbi.nlm.nih.gov/geo/query/acc.cgi?acc=GSE221359)
+
+---
+
+### Directories and Files ###
+- SampleSheet.csv: names of samples and corresponding treatment condisions
+- scripts: folder with R scripts used for the analyses
+  - `0_Compute_Zones.R`: initial analysis with Full object creation and zonation;
+  - `1_GSEA_Visualization.R`: analysis on zones with GSEA;
+  - `2_SigZones_Visualization.R`: in depth characterization of zones with signatures.
+- data: results of the analyses
+  - GSEA_Zones_unique_integrated.res01.txt;
+  - Zones_unique.integrated.txt;
+  - crc.integrated_metadata.csv.gz;
+  - miDB_sig3.rds.
+
+---
+
+### Analyses ###
+
 Spatial Transcriptomics data of Liver Tumor paper.