@@ -36,7 +36,7 @@ For Thal vs HD comparison intra population (HSC or MPP - n = 2) we used the simp
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@@ -36,7 +36,7 @@ For Thal vs HD comparison intra population (HSC or MPP - n = 2) we used the simp
We performed Over Representation Analyses (ORA) and Gene Set Enrichment Analyses (GSEA) using R/Bioconductor package [clusterProfiler](https://bioconductor.org/packages/release/bioc/html/clusterProfiler.html)(v.3.8.1). Pre-ranked gene list according to log2FC was used to perform Gene Set Enrichment Analysis (GSEA). Terms with adjusted p-value (Benjiamini-Hochberg correction) less than 0.05 were considered significantly enriched.
We performed Over Representation Analyses (ORA) and Gene Set Enrichment Analyses (GSEA) using R/Bioconductor package [clusterProfiler](https://bioconductor.org/packages/release/bioc/html/clusterProfiler.html)(v.3.8.1). Pre-ranked gene list according to log2FC was used to perform Gene Set Enrichment Analysis (GSEA). Terms with adjusted p-value (Benjiamini-Hochberg correction) less than 0.05 were considered significantly enriched.
7. Supplementary analysis: Music deconvolution analysis
7. Supplementary analysis
We also applied Music to perform BulkRNAseq deconvolution according to celltype specific transcriptomic profiles obtained from scRNAseq dataset (Tusi et al 2021).
We also applied Music to perform BulkRNAseq deconvolution according to celltype specific transcriptomic profiles obtained from scRNAseq dataset (Tusi et al 2021).
