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Vavassori_LNP2022
Vavassori_LNP2022_RNAseq_lnps
Commits
42c6d9d3
Commit
42c6d9d3
authored
Oct 17, 2022
by
Stefano Beretta
Browse files
Added paper data.
parent
38efa0d0
Changes
62
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paper_data/HSPC_DGE.rds
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42c6d9d3
File added
paper_data/HSPC_LNPsRNA-HSPC_UT-enr-h.all.v7.2.symbols-neg.txt
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42c6d9d3
ID Description GeneRatio BgRatio pvalue p.adjust qvalue geneID Count
HALLMARK_E2F_TARGETS HALLMARK_E2F_TARGETS 76/362 200/3429 1.22692302788824e-26 5.76653823107474e-25 5.16599169637155e-25 MYBL2/UNG/TK1/EZH2/LMNB1/MCM7/MCM4/CENPM/TCF19/MCM3/TIMELESS/HMGB3/KIF22/SMC1A/LIG1/RRM2/ASF1B/WDR90/POLE/POLD2/ESPL1/SSRP1/STMN1/ANP32E/MCM6/H2AZ1/SHMT1/H2AX/UBE2S/MCM2/RFC2/DDX39A/MXD3/CIT/POLD1/CDC25A/DNMT1/TACC3/MKI67/GINS3/CDKN2C/RANBP1/XRCC6/GINS4/MCM5/POP7/E2F8/TRA2B/CDCA3/HMGB2/DLGAP5/RAD51AP1/NOP56/SUV39H1/RBBP7/UBR7/CCNE1/SLBP/DONSON/KIF18B/SPAG5/RPA2/BIRC5/MSH2/GINS1/PRPS1/NUP205/UBE2T/HELLS/SRSF2/CTCF/SPC24/NCAPD2/NAA38/KIF4A/NASP 76
HALLMARK_CHOLESTEROL_HOMEOSTASIS HALLMARK_CHOLESTEROL_HOMEOSTASIS 29/362 64/3429 7.2505860227843e-13 1.70388771535431e-11 1.52643916269143e-11 HMGCS1/HMGCR/SQLE/LDLR/ACAT2/LSS/FDFT1/SCD/MVD/MVK/IDI1/TM7SF2/FADS2/FDPS/CYP51A1/SREBF2/DHCR7/TMEM97/PCYT2/FASN/ALDOC/STARD4/HSD17B7/SC5D/EBP/NSDHL/ACSS2/ATF5/ABCA2 29
HALLMARK_G2M_CHECKPOINT HALLMARK_G2M_CHECKPOINT 49/362 196/3429 2.09847871751454e-09 3.28761665743944e-08 2.9452332877397e-08 SQLE/MYBL2/CDC6/EZH2/LMNB1/MCM3/HMGB3/KIF22/SMC1A/DTYMK/CDC45/POLE/ESPL1/STMN1/MCM6/GINS2/FBXO5/H2AZ1/EWSR1/H2AX/UBE2S/MCM2/ATF5/DDX39A/E2F2/HMGN2/CDC25A/E2F1/CHAF1A/TACC3/MKI67/CDKN2C/MCM5/CHMP1A/KPNB1/TRA2B/SFPQ/KMT5A/SUV39H1/INCENP/TFDP1/RPA2/BIRC5/H2AZ2/SRSF2/CTCF/KIF4A/NASP/CCNF 49
HALLMARK_MTORC1_SIGNALING HALLMARK_MTORC1_SIGNALING 47/362 195/3429 1.6653281936229e-08 1.9567606275069e-07 1.75297704591884e-07 DHCR24/HMGCS1/HMGCR/INSIG1/SQLE/LDLR/SCD/IDI1/TM7SF2/FADS2/CYP51A1/DHCR7/TMEM97/FADS1/ELOVL6/STARD4/SC5D/EBP/IDH1/ACACA/ACLY/UNG/RDH11/CYB5B/MCM4/RRM2/ACSL3/PIK3R3/HSPA5/ADIPOR2/MCM2/TOMM40/DDX39A/CDC25A/SDF2L1/G6PD/DHFR/YKT6/SLC37A4/PPIA/HMBS/ELOVL5/NUP205/CALR/SLC9A3R1/ENO1/CCNF 47
HALLMARK_MYC_TARGETS_V2 HALLMARK_MYC_TARGETS_V2 14/362 57/3429 0.00182999576343468 0.017201960176286 0.0154104906394499 TMEM97/SLC29A2/UNG/MCM4/LAS1L/SLC19A1/MCM5/NOP56/GRWD1/MRTO4/PUS1/MAP3K6/PPRC1/NOC4L 14
HALLMARK_MYC_TARGETS_V1 HALLMARK_MYC_TARGETS_V1 34/362 200/3429 0.00279503956520046 0.0218944765940703 0.0196143127382488 MCM7/MCM4/CDC45/POLD2/SRSF7/MCM6/H2AZ1/MCM2/POLE3/CDK2/RANBP1/XRCC6/MCM5/KPNB1/TRA2B/PRPF31/PSMA7/PPM1G/NOP56/YWHAQ/HNRNPA2B1/RRM1/TFDP1/PPIA/SET/RNPS1/EIF3B/GOT2/SNRPA/SRSF2/SF3B3/TYMS/DHX15/SNRPD3 34
paper_data/HSPC_LNPsRNA-HSPC_UT-enr-h.all.v7.2.symbols-pos.txt
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42c6d9d3
ID Description GeneRatio BgRatio pvalue p.adjust qvalue geneID Count
HALLMARK_P53_PATHWAY HALLMARK_P53_PATHWAY 54/407 177/3429 6.58210105898105e-12 3.29105052949053e-10 2.42498460067723e-10 PHLDA3/ZMAT3/CDKN1A/FDXR/AEN/RPS27L/DDB2/MDM2/BAX/SESN1/XPC/POLH/JUN/BTG2/IER5/GADD45A/DRAM1/SDC1/TRIAP1/PLXNB2/ADA/DDIT4/FAS/CCNG1/TNFSF9/EPHA2/PLK2/PPM1D/PROCR/ATF3/PTPN14/PLK3/TM7SF3/DGKA/ISCU/PDGFA/CYFIP2/LIF/FUCA1/RGS16/PPP1R15A/RNF19B/APP/PITPNC1/TOB1/EPS8L2/SLC7A11/TAP1/APAF1/CD82/HMOX1/RHBDF2/CASP1/FAM162A 54
HALLMARK_INFLAMMATORY_RESPONSE HALLMARK_INFLAMMATORY_RESPONSE 38/407 135/3429 1.27100815311973e-07 3.17752038279932e-06 2.34133080837844e-06 CDKN1A/ABCA1/BTG2/TNFSF9/AXL/CD55/SCN1B/CD70/STAB1/IL4R/CD48/TNFSF10/AHR/BST2/RASGRP1/LIF/CXCL8/CSF1/ATP2C1/P2RX7/RGS16/GNA15/EIF2AK2/IRAK2/CD69/IL1B/GABBR1/IL18/GPR132/PLAUR/OSM/CHST2/MMP14/RGS1/ICAM1/CD82/NLRP3/NFKB1 38
HALLMARK_EPITHELIAL_MESENCHYMAL_TRANSITION HALLMARK_EPITHELIAL_MESENCHYMAL_TRANSITION 36/407 129/3429 3.52487133300014e-07 4.46950611204211e-06 3.29332029308366e-06 ACTA2/JUN/GADD45A/SDC1/FAS/VIM/CD44/LRP1/COL5A1/LAMC1/MMP2/FBLN2/TIMP3/TPM4/FSTL1/CXCL8/FUCA1/IGFBP4/ELN/THBS1/SERPINH1/PFN2/DST/CTHRC1/ITGA2/ENO2/COL8A2/CAPG/PLAUR/VEGFA/MMP14/LOX/CALU/COPA/NOTCH2/PMP22 36
HALLMARK_IL2_STAT5_SIGNALING HALLMARK_IL2_STAT5_SIGNALING 43/407 168/3429 3.57560488963369e-07 4.46950611204211e-06 3.29332029308366e-06 ANXA4/PLIN2/CD44/HK2/IL4R/RRAGD/CD48/TNFSF10/SH3BGRL2/DENND5A/NCOA3/AHR/PLSCR1/SWAP70/NCS1/LIF/CSF1/CTSZ/MYO1E/ST3GAL4/P4HA1/CKAP4/SYT11/RGS16/BATF3/GALM/SNX9/TRAF1/GUCY1B1/PRKCH/RABGAP1L/PRNP/BMPR2/SLC2A3/IL2RA/CCR4/CAPG/IGF2R/F2RL2/PLEC/NFIL3/MYO1C/TTC39B 43
HALLMARK_APOPTOSIS HALLMARK_APOPTOSIS 37/407 140/3429 1.0664630482357e-06 1.0664630482357e-05 7.8581487764736e-06 CDKN1A/FDXR/BAX/JUN/CD38/BTG2/GADD45A/FAS/CD44/ATF3/MMP2/LMNA/TNFSF10/TIMP3/PTK2/GPX1/PMAIP1/CCNA1/BIRC3/GNA15/CDC25B/CASP4/APP/CD69/IL1B/ROCK1/ENO2/BCL2L2/IL18/IGF2R/TOP2A/TAP1/HMOX1/DFFA/CASP1/CASP8/SQSTM1 37
HALLMARK_TNFA_SIGNALING_VIA_NFKB HALLMARK_TNFA_SIGNALING_VIA_NFKB 41/407 170/3429 3.64384601808254e-06 3.03653834840212e-05 2.23744930934893e-05 CDKN1A/ABCA1/JUN/BTG2/IER5/GADD45A/DRAM1/CD44/TNFSF9/PLK2/ATF3/DUSP4/PLAU/EIF1/DENND5A/FOSL1/LIF/CSF1/LAMB3/PNRC1/PPP1R15A/BIRC3/TRIP10/NR4A1/TRAF1/RNF19B/NFAT5/CD69/IL1B/SLC2A3/IL18/TAP1/SMAD3/PLAUR/VEGFA/LITAF/ICAM1/NFIL3/CXCL3/NFKB1/SQSTM1 41
HALLMARK_KRAS_SIGNALING_UP HALLMARK_KRAS_SIGNALING_UP 30/407 127/3429 0.000118196035911739 0.000844257399369568 0.000622084399535471 ADGRA2/CCSER2/SCN1B/PLAU/CTSS/GPNMB/ST6GAL1/ZNF277/LIF/CROT/CXCR4/ETS1/FUCA1/ACE/RGS16/PPP1R15A/BIRC3/PRDM1/TRAF1/PLVAP/RABGAP1L/EPB41L3/LY96/ITGA2/IL1B/TSPAN7/USP12/PLAUR/CBL/LAT2 30
HALLMARK_HYPOXIA HALLMARK_HYPOXIA 31/407 156/3429 0.00218644169908488 0.0136652606192805 0.0100691394036804 CDKN1A/JUN/PLIN2/DDIT4/COL5A1/ATF3/HK2/PGF/RRAGD/P4HA2/HS3ST1/VLDLR/PAM/CXCR4/ETS1/P4HA1/PNRC1/PPP1R15A/NR3C1/MXI1/ENO2/KIF5A/SLC2A3/PLAUR/VEGFA/CHST2/NFIL3/HMOX1/LOX/PDK3/FAM162A 31
HALLMARK_INTERFERON_ALPHA_RESPONSE HALLMARK_INTERFERON_ALPHA_RESPONSE 20/407 92/3429 0.00460100063854256 0.0255611146585698 0.0188345055378935 TRIM5/PROCR/IL4R/B2M/BST2/PLSCR1/CSF1/LPAR6/GBP2/PSMB9/EIF2AK2/PARP14/TAP1/SAMD9L/TENT5A/DDX60/CASP1/UBE2L6/SP110/CASP8 20
HALLMARK_INTERFERON_GAMMA_RESPONSE HALLMARK_INTERFERON_GAMMA_RESPONSE 32/407 176/3429 0.00778886096023671 0.0389443048011835 0.0286958035377142 CDKN1A/CD38/FAS/HLA-A/IL4R/HLA-B/B2M/TNFSF10/NCOA3/BST2/PLSCR1/OAS2/ZNFX1/PSMB9/EIF2AK2/CASP4/MVP/ITGB7/CD69/SLAMF7/PARP14/TAP1/SAMD9L/ICAM1/DDX60/CASP1/UBE2L6/EIF4E3/SP110/RNF213/CASP8/NFKB1 32
HALLMARK_IL6_JAK_STAT3_SIGNALING HALLMARK_IL6_JAK_STAT3_SIGNALING 15/407 66/3429 0.0088038886748034 0.0389497191217939 0.0286997930371113 JUN/CD38/FAS/CD44/IL4R/CSF1/PDGFC/CD9/IL1B/IL2RA/CBL/HMOX1/IL12RB1/CXCL3/LEPR 15
HALLMARK_ALLOGRAFT_REJECTION HALLMARK_ALLOGRAFT_REJECTION 27/407 144/3429 0.00934793258923053 0.0389497191217939 0.0286997930371113 FAS/HLA-A/PRKCB/ITGAL/STAB1/IL4R/HLA-DOA/CTSS/B2M/HLA-E/LIF/CSF1/ETS1/GBP2/RPS19/IL1B/IL2RA/IL18/CAPG/PTPRC/TAP1/GCNT1/ICAM1/NCF4/IL12RB1/NLRP3/TAP2 27
paper_data/HSPC_LNPsRNA-HSPC_UTelectro-enr-h.all.v7.2.symbols-neg.txt
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ID Description GeneRatio BgRatio pvalue p.adjust qvalue geneID Count
HALLMARK_CHOLESTEROL_HOMEOSTASIS HALLMARK_CHOLESTEROL_HOMEOSTASIS 36/466 66/3589 4.59003140804278e-16 2.29501570402139e-14 1.64274808287847e-14 HMGCS1/HMGCR/SQLE/LDLR/ACAT2/FDFT1/LSS/MVD/SCD/IDI1/MVK/TM7SF2/FDPS/FADS2/CYP51A1/SREBF2/CD9/DHCR7/STARD4/ALDOC/TMEM97/HSD17B7/FASN/PCYT2/SC5D/ANTXR2/NSDHL/ACSS2/EBP/CLU/GNAI1/TNFRSF12A/TRIB3/ATF5/CXCL16/AVPR1A 36
HALLMARK_EPITHELIAL_MESENCHYMAL_TRANSITION HALLMARK_EPITHELIAL_MESENCHYMAL_TRANSITION 40/466 144/3589 1.05627569222695e-06 2.64068923056737e-05 1.89017755451138e-05 ECM1/LGALS1/GPC1/ID2/ITGB5/VIM/TIMP3/MMP14/PRSS2/ELN/CD44/THBS1/TIMP1/SFRP4/SDC4/FLNA/SCG2/SPP1/DAB2/GEM/INHBA/NT5E/ITGB3/CXCL8/TNFRSF12A/VCAN/EMP3/TGFB1/SERPINE1/PMP22/COL6A2/COL6A3/LRP1/MCM7/GJA1/SPARC/PMEPA1/COL7A1/HTRA1/PDLIM4 40
HALLMARK_IL2_STAT5_SIGNALING HALLMARK_IL2_STAT5_SIGNALING 45/466 174/3589 1.95507240220199e-06 3.25845400366999e-05 2.33236707631115e-05 PLEC/ECM1/NCS1/IL1RL1/CSF1/SLC29A2/TNFRSF18/SLC2A3/HOPX/PIM1/EMP1/BHLHE40/CD44/CDC6/AHR/TNFRSF4/AHNAK/KLF6/CDKN1C/IL4R/CDCP1/LIF/IL18R1/SOCS2/COL6A1/SPP1/NT5E/MYO1C/NRP1/MAFF/IL10RA/IL2RB/MXD1/NDRG1/NFKBIZ/IL2RA/PNP/LTB/GSTO1/SPRY4/CISH/RORA/CCND3/NOP2/TRAF1 45
HALLMARK_COAGULATION HALLMARK_COAGULATION 27/466 90/3589 1.38320451301157e-05 0.000172900564126446 0.000123760403795772 CD9/GSN/PROS1/CAPN2/VWF/TIMP3/MMP14/PRSS23/ANXA1/DUSP6/CLU/THBS1/TIMP1/CRIP2/RAPGEF3/DUSP14/ITGB3/MAFF/SERPINE1/MMP7/LRP1/THBD/RABIF/SPARC/WDR1/HTRA1/RAC1 27
HALLMARK_TNFA_SIGNALING_VIA_NFKB HALLMARK_TNFA_SIGNALING_VIA_NFKB 42/466 176/3589 3.7519625211427e-05 0.00037519625211427 0.000268561527829162 LDLR/NR4A1/EGR3/PPP1R15A/CSF1/SLC2A3/ID2/LAMB3/PHLDA2/BHLHE40/CD44/SQSTM1/SPHK1/KLF6/CCL5/CCND1/SLC2A6/KLF10/NR4A2/RELB/PTGS2/LIF/SDC4/SOD2/PTGER4/EGR1/GEM/INHBA/TRIB1/DUSP5/SOCS3/MAFF/SERPINE1/CCL2/MXD1/STAT5A/ZC3H12A/EGR2/MCL1/PMEPA1/MAP2K3/TRAF1 42
HALLMARK_INFLAMMATORY_RESPONSE HALLMARK_INFLAMMATORY_RESPONSE 35/466 143/3589 9.86506033569302e-05 0.000822088361307752 0.000588442195462391 LDLR/CSF1/MMP14/SEMA4D/STAB1/AHR/TIMP1/SPHK1/KLF6/CCL5/C5AR1/IL4R/C3AR1/LIF/IL18R1/PTGER4/DCBLD2/INHBA/ITGB3/RGS1/CXCL8/SLC7A1/LCP2/PTGIR/EMP3/IL10RA/SERPINE1/IL2RB/CCL2/MXD1/EREG/AXL/IRF7/CD55/ADORA2B 35
HALLMARK_ANDROGEN_RESPONSE HALLMARK_ANDROGEN_RESPONSE 24/466 91/3589 0.00038396382696144 0.00274259876401028 0.00196312332581789 HMGCS1/HMGCR/INSIG1/DHCR24/SCD/IDI1/FADS1/GUCY1A1/ABHD2/KRT8/CCND1/PTK2B/H1-0/ARID5B/ACSL3/CDK6/NDRG1/ZMIZ1/ELOVL5/KRT19/PMEPA1/CCND3/SRF/ELL2 24
HALLMARK_MTORC1_SIGNALING HALLMARK_MTORC1_SIGNALING 42/466 196/3589 0.000490154574601854 0.00306346609126159 0.00219279678111356 HMGCS1/HMGCR/INSIG1/SQLE/LDLR/DHCR24/SCD/IDI1/TM7SF2/FADS2/CYP51A1/CD9/DHCR7/STARD4/TMEM97/FADS1/SC5D/PPP1R15A/SLC2A3/SLA/EBP/ELOVL6/BHLHE40/RDH11/SQSTM1/ACLY/DDIT3/ACACA/CYB5B/UNG/IDH1/MCM4/ADIPOR2/RRM2/TRIB3/ACSL3/ENO1/PNP/ELOVL5/YKT6/SLC6A6/MAP2K3 42
HALLMARK_APOPTOSIS HALLMARK_APOPTOSIS 33/466 145/3589 0.000657291794463544 0.00365162108035302 0.00261379193120006 GSN/EGR3/SC5D/TXNIP/TIMP3/LMNA/EBP/BMF/ANXA1/EMP1/CLU/CD44/SLC20A1/TIMP1/SQSTM1/DDIT3/CCND1/SOD2/CCNA1/ISG20/H1-0/KRT18/CASP2/TNFRSF12A/PEA15/EREG/MADD/MCL1/HGF/ERBB2/BCL2L11/GPX1/AVPR1A 33
HALLMARK_MYOGENESIS HALLMARK_MYOGENESIS 31/466 137/3589 0.00105699491115044 0.00528497455575221 0.00378292915569632 SCD/FDPS/CD36/KIFC3/GSN/LPIN1/ITGB5/PTP4A3/CNN3/CLU/BHLHE40/SPHK1/CAMK2B/HDAC5/DMPK/TNNT1/MYO1C/CACNA1H/AEBP1/TGFB1/ITGB4/ATP2A1/COL6A2/PDLIM7/COL6A3/ITGA7/BAG1/MYH9/MYH3/SPARC/MEF2D 31
HALLMARK_ESTROGEN_RESPONSE_EARLY HALLMARK_ESTROGEN_RESPONSE_EARLY 33/466 159/3589 0.00339694246474378 0.0154406475670172 0.0110522529953386 FDFT1/DLC1/DHCR7/FASN/EGR3/ENDOD1/ABHD2/PRSS23/TMEM164/FHL2/BHLHE40/CD44/KCNK5/NRIP1/KRT8/CCND1/KLF10/AQP3/DHRS2/KRT18/AR/CELSR1/ELF1/SLC24A3/ELOVL5/BAG1/TTC39A/CISH/GJA1/KRT19/IL17RB/RET/MAST4 33
HALLMARK_KRAS_SIGNALING_UP HALLMARK_KRAS_SIGNALING_UP 29/466 138/3589 0.00489166714213366 0.0203819464255569 0.0145891827046092 VWA5A/PPP1R15A/ACE/ID2/GUCY1A1/EMP1/DUSP6/TMEM158/LAT2/LAPTM5/C3AR1/PTGS2/LIF/DCBLD2/SPP1/F13A1/INHBA/KCNN4/PCSK1N/TRIB1/MYCN/NRP1/WNT7A/ADAM8/IL10RA/EREG/JUP/PTBP2/TRAF1 29
HALLMARK_UV_RESPONSE_DN HALLMARK_UV_RESPONSE_DN 26/466 123/3589 0.00695313215874911 0.0267428159951889 0.0191422261860299 INSIG1/LDLR/DLC1/ANXA2/FHL2/BHLHE40/CELF2/DAB2/MAP1B/SYNJ2/ITGB3/NRP1/SLC7A1/SERPINE1/PMP22/ZMIZ1/WDR37/ATXN1/ADORA2B/GJA1/ERBB2/MGLL/RUNX1/PIAS3/GRK5/SYNE1 26
paper_data/HSPC_LNPsRNA-HSPC_UTelectro-enr-h.all.v7.2.symbols-pos.txt
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ID Description GeneRatio BgRatio pvalue p.adjust qvalue geneID Count
HALLMARK_P53_PATHWAY HALLMARK_P53_PATHWAY 64/643 180/3589 5.02976783431596e-09 2.51488391715798e-07 2.22368683201337e-07 ZMAT3/FDXR/PHLDA3/AEN/BAX/DDB2/DRAM1/TM7SF3/SESN1/RPS27L/POLH/TAP1/GM2A/CCNG1/MDM2/TRIAP1/ADA/APP/FAS/PROCR/TNFSF9/IER5/PLK2/CDKN1A/XPC/RXRA/FUCA1/APAF1/BTG2/PLXNB2/PPM1D/HINT1/ALOX15B/SDC1/VAMP8/CASP1/TPD52L1/CEBPA/ACVR1B/FAM162A/NINJ1/CYFIP2/GADD45A/MKNK2/CCP110/RNF19B/SLC35D1/F2R/IRAK1/ISCU/IRAG2/SLC7A11/SEC61A1/RGS16/PIDD1/RHBDF2/FOXO3/EI24/SLC19A2/TSC22D1/CTSD/TOB1/EPHA2/NUDT15 64
HALLMARK_INTERFERON_ALPHA_RESPONSE HALLMARK_INTERFERON_ALPHA_RESPONSE 29/643 93/3589 0.00116107529111303 0.0290268822778258 0.0256658748561828 TAP1/TENT5A/B2M/PSMB9/BST2/TRIM5/PROCR/PSMB8/SELL/HLA-C/PSME1/CASP1/UBE2L6/SAMD9L/SP110/EPSTI1/IL7/IFIT2/IFIH1/PARP9/EIF2AK2/IFI44L/LPAR6/PARP14/TRIM26/LAMP3/MVB12A/DDX60/PSME2 29
paper_data/HSPC_LNPsRNA-HSPC_electroRNA-enr-h.all.v7.2.symbols-neg.txt
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42c6d9d3
ID Description GeneRatio BgRatio pvalue p.adjust qvalue geneID Count
HALLMARK_CHOLESTEROL_HOMEOSTASIS HALLMARK_CHOLESTEROL_HOMEOSTASIS 38/505 66/3619 6.91646771174295e-17 3.45823385587148e-15 2.40256246828966e-15 HMGCS1/HMGCR/FDFT1/SQLE/LDLR/ACAT2/LSS/MVD/SCD/MVK/IDI1/TM7SF2/FDPS/SREBF2/CYP51A1/FADS2/STARD4/CD9/DHCR7/HSD17B7/FASN/ALDOC/TMEM97/PCYT2/SC5D/NSDHL/ANTXR2/EBP/GNAI1/ACSS2/CLU/CXCL16/TNFRSF12A/ABCA2/TP53INP1/TRIB3/ACTG1/AVPR1A 38
HALLMARK_TNFA_SIGNALING_VIA_NFKB HALLMARK_TNFA_SIGNALING_VIA_NFKB 52/505 179/3619 5.26188543258099e-08 1.31547135814525e-06 9.1390641723775e-07 LDLR/EGR3/CSF1/NR4A1/PPP1R15A/ID2/SLC2A3/CD44/CDKN1A/LAMB3/BHLHE40/PTGER4/PHLDA2/SQSTM1/CCND1/CCL5/LIF/PTGS2/RELB/EGR1/NR4A2/INHBA/SDC4/SPHK1/SLC2A6/KLF6/GADD45A/DUSP5/KLF10/MXD1/TRIB1/SERPINE1/TRAF1/MAFF/GEM/PTPRE/MCL1/NFKB2/RHOB/IER5/SOD2/FOSL1/STAT5A/TNIP1/EGR2/PMEPA1/GADD45B/CCL2/CFLAR/IER3/NFKBIA/PLK2 52
HALLMARK_EPITHELIAL_MESENCHYMAL_TRANSITION HALLMARK_EPITHELIAL_MESENCHYMAL_TRANSITION 44/505 147/3619 2.35081358115149e-07 3.91802263525249e-06 2.72199467291226e-06 ECM1/GPC1/LGALS1/MMP14/ID2/TIMP3/VIM/ITGB5/CD44/THBS1/PRSS2/ELN/LRP1/FLNA/INHBA/TIMP1/SDC4/DAB2/SPP1/GADD45A/SFRP4/SERPINE1/TGFB1/CXCL8/ACTA2/SCG2/GEM/COL6A2/VCAN/NT5E/RHOB/ITGB3/GJA1/FMOD/TNFRSF12A/COL6A3/HTRA1/PMEPA1/GADD45B/SDC1/CAPG/PDLIM4/MCM7/PMP22 44
HALLMARK_P53_PATHWAY HALLMARK_P53_PATHWAY 48/505 181/3619 3.39632621919888e-06 4.2454077739986e-05 2.94944119035692e-05 VWA5A/TM4SF1/S100A10/PPP1R15A/MDM2/CDKN1A/DGKA/TXNIP/ABHD4/XPC/LIF/PLXNB2/STOM/TSPYL2/UPP1/PLK3/ZBTB16/RPS27L/DDIT3/SPHK1/GADD45A/MXD1/TGFB1/S100A4/BAIAP2/PHLDA3/DDB2/PTPRE/PVT1/VDR/FDXR/NOTCH1/IER5/CYFIP2/AEN/EPHA2/SDC1/TRIB3/CTSF/PDGFA/PTPN14/IER3/CCND3/RALGDS/CDKN2AIP/PCNA/PLK2/SLC3A2 48
HALLMARK_IL2_STAT5_SIGNALING HALLMARK_IL2_STAT5_SIGNALING 45/505 175/3619 1.67377978302914e-05 0.000167377978302914 0.00011628364808413 PLEC/ECM1/NCS1/IL1RL1/CSF1/SLC29A2/SLC2A3/TNFRSF18/CD44/HOPX/BHLHE40/PIM1/AHR/IL4R/EMP1/CDKN1C/LIF/CDCP1/AHNAK/CDC6/COL6A1/TNFRSF4/IL18R1/SPP1/KLF6/IL2RB/MXD1/IL10RA/TRAF1/MAFF/NRP1/NFKBIZ/NT5E/SPRY4/CAPN3/SOCS2/RHOB/MYO1C/HUWE1/NOP2/P2RX4/GADD45B/RORA/CAPG/CCND3 45
HALLMARK_APOPTOSIS HALLMARK_APOPTOSIS 39/505 145/3619 2.0653054824754e-05 0.000172108790206283 0.00011957031740647 EGR3/GSN/LMNA/TIMP3/SC5D/CD44/CDKN1A/EBP/TXNIP/CCNA1/BMF/EMP1/SQSTM1/SLC20A1/CCND1/ANXA1/TIMP1/DDIT3/CASP2/GADD45A/CLU/GPX1/KRT18/FDXR/MCL1/RHOB/PEA15/ERBB2/SOD2/CAV1/TNFRSF12A/MADD/GADD45B/PTK2/EREG/AVPR1A/CFLAR/IER3/PLAT 39
HALLMARK_INFLAMMATORY_RESPONSE HALLMARK_INFLAMMATORY_RESPONSE 38/505 146/3619 5.85346017267963e-05 0.000418104298048545 0.000290472459696884 LDLR/CSF1/MMP14/SEMA4D/CDKN1A/STAB1/PTGER4/AHR/IL4R/CCL5/LIF/C3AR1/C5AR1/INHBA/TIMP1/RGS1/IL18R1/SPHK1/KLF6/PTGIR/IL2RB/MXD1/DCBLD2/SERPINE1/CXCL8/IRF7/IL10RA/PTPRE/SLC7A1/LCP2/ITGB3/CD55/P2RX4/EREG/AXL/CCL2/HIF1A/NFKBIA 38
HALLMARK_MYOGENESIS HALLMARK_MYOGENESIS 35/505 139/3619 0.000234310653130446 0.00146444158206529 0.00101740152017167 SCD/FDPS/CD36/GSN/KIFC3/LPIN1/PTP4A3/ITGB5/CDKN1A/BHLHE40/CNN3/HDAC5/PLXNB2/CAMK2B/SPHK1/CLU/AGRN/TGFB1/AEBP1/MEF2D/COL6A2/MYH9/ATP2A1/NOTCH1/ITGA7/EFS/MYO1C/CACNA1H/PDLIM7/COL6A3/GADD45B/MYH11/DMPK/GJA5/BAG1 35
HALLMARK_COAGULATION HALLMARK_COAGULATION 25/505 90/3619 0.000379125897666208 0.00210625498703449 0.0014632929383608 CD9/MMP14/PROS1/GSN/VWF/CAPN2/TIMP3/DUSP6/PRSS23/THBS1/LRP1/ANXA1/CRIP2/TIMP1/RAPGEF3/CLU/SERPINE1/MAFF/DUSP14/ITGB3/WDR1/THBD/MMP7/HTRA1/PLAT 25
HALLMARK_ANDROGEN_RESPONSE HALLMARK_ANDROGEN_RESPONSE 22/505 92/3619 0.00652949841644917 0.0326474920822458 0.0226814155518761 HMGCS1/HMGCR/INSIG1/DHCR24/SCD/IDI1/FADS1/ABHD2/GUCY1A1/PTK2B/CCND1/KRT8/ZMIZ1/CDK6/AKAP12/ELOVL5/ELL2/ACSL3/ARID5B/PMEPA1/SRF/CCND3 22
HALLMARK_HEDGEHOG_SIGNALING HALLMARK_HEDGEHOG_SIGNALING 9/505 27/3619 0.0084579917136519 0.0384454168802359 0.0267094475167955 HEY1/CDK6/CELSR1/SCG2/NRP1/MYH9/NRP2/TLE3/RTN1 9
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ID Description GeneRatio BgRatio pvalue p.adjust qvalue geneID Count
HALLMARK_OXIDATIVE_PHOSPHORYLATION HALLMARK_OXIDATIVE_PHOSPHORYLATION 73/664 199/3619 2.27590124324463e-10 1.13795062162231e-08 1.00618791806605e-08 NNT/SLC25A5/ACAT1/OAT/COX7C/ACADSB/ETFA/IDH2/LDHA/COX7A2L/CASP7/ATP5F1B/GOT2/MRPS15/COX11/MDH2/PRDX3/COX6A1/COX7A2/AIFM1/ALDH6A1/HADHA/GPI/UQCRC2/ATP5F1A/HTRA2/SUCLG1/NDUFS3/OPA1/RHOT1/NDUFV1/MPC1/ATP5PB/ATP5MC3/MRPL34/COX7B/NDUFS7/CS/SDHD/NDUFS2/UQCRH/COX5A/ATP6V0E1/ATP5F1C/NDUFA2/NDUFA3/COX4I1/ABCB7/HADHB/PDHA1/DLD/COX8A/IDH3B/NDUFS6/ATP5MC1/UQCRB/UQCRC1/NDUFA4/VDAC2/ATP5PD/NDUFAB1/HSPA9/FDX1/NDUFA1/UQCRQ/NDUFB6/TIMM9/COX5B/ACAA1/SDHC/NDUFB2/MRPL11/SDHB 73
HALLMARK_HEME_METABOLISM HALLMARK_HEME_METABOLISM 56/664 187/3619 5.11252548223729e-05 0.00127813137055932 0.00113013721186298 CTSB/ALAD/TENT5C/NNT/KLF1/TFRC/EPOR/LAMP2/BNIP3L/FECH/GYPC/ACP5/BLVRB/HEBP1/TRIM58/AHSP/MARCHF8/ALAS2/KLF3/TMCC2/SLC25A38/TFDP2/SELENBP1/IGSF3/CLIC2/ALDH6A1/GYPE/BLVRA/SEC14L1/SLC7A11/PICALM/HTRA2/EPB41/CAT/SLC11A2/PRDX2/EPB42/XPO7/CPOX/CLCN3/FN3K/KEL/SLC66A2/GCLC/BCAM/GDE1/SIDT2/NFE2/TOP1/NR3C1/FOXO3/NARF/ABCG2/TAL1/BPGM/GATA1 56
HALLMARK_GLYCOLYSIS HALLMARK_GLYCOLYSIS 50/664 172/3619 0.000293064176467568 0.00488440294112614 0.00431884049531153 COL5A1/CHST2/CXCR4/RRAGD/PYGL/FKBP4/HK2/TALDO1/ALDH7A1/GUSB/B4GALT1/EXT2/PAM/GLRX/BIK/LDHA/ERO1A/ME2/GOT2/MDH2/P4HA1/FAM162A/PGK1/RPE/SLC37A4/TXN/PLOD2/SLC25A10/B4GALT4/GCLC/VLDLR/GALK2/AK4/PLOD1/ALDH9A1/DLD/CASP6/HS2ST1/LHPP/AK3/STMN1/GLCE/AGL/FUT8/SOD1/PGM2/PKP2/SDHC/AKR1A1/CLDN9 50
HALLMARK_ADIPOGENESIS HALLMARK_ADIPOGENESIS 49/664 179/3619 0.00149138973399785 0.0171282305089358 0.0151449617131643 ABCA1/TALDO1/APOE/TST/PGM1/HADH/APLP2/FAH/DHRS7/HIBCH/ATP1B3/ALDH2/VEGFB/ESRRA/PPP1R15B/MDH2/PRDX3/COQ3/COX6A1/AIFM1/CD302/RTN3/AK2/SUCLG1/NDUFS3/CAT/LPCAT3/PTGER3/COX7B/CHCHD10/CS/CMBL/SLC25A10/GHITM/DLD/COX8A/UQCRC1/SAMM50/NDUFAB1/IFNGR1/ACADS/EPHX2/UQCRQ/SOD1/PDCD4/SDHC/BCL6/SDHB/SLC1A5 49
HALLMARK_INTERFERON_ALPHA_RESPONSE HALLMARK_INTERFERON_ALPHA_RESPONSE 29/664 93/3619 0.00171282305089358 0.0171282305089358 0.0151449617131643 SELL/PSMB9/B2M/TAP1/EPSTI1/TENT5A/PSMB8/IL7/PSME1/PROCR/BST2/IFIT2/TRIM26/CASP1/SAMD9L/CMPK2/UBE2L6/HLA-C/EIF2AK2/IFIT3/MVB12A/IFI44L/PARP9/OAS1/PSME2/LAMP3/LPAR6/IFITM3/LGALS3BP 29
HALLMARK_INTERFERON_GAMMA_RESPONSE HALLMARK_INTERFERON_GAMMA_RESPONSE 48/664 183/3619 0.00427327095307764 0.0326615227433057 0.0288796622151335 CSF2RB/PSMB9/B2M/TAP1/ITGB7/EPSTI1/VAMP8/HLA-A/SERPING1/PSMB8/IL7/OAS2/PSME1/TNFSF10/TNFAIP2/APOL6/BST2/IFIT1/IFIT2/TRIM26/CASP7/CFH/CASP1/SAMD9L/SELP/HLA-B/OAS3/CMPK2/UBE2L6/EIF4E3/SAMHD1/EIF2AK2/PDE4B/ICAM1/CASP4/IFIT3/ISOC1/HLA-DRB1/IFI44L/AUTS2/NFKB1/PSME2/CD38/GZMA/ST3GAL5/BPGM/IFITM3/LGALS3BP 48
HALLMARK_REACTIVE_OXYGEN_SPECIES_PATHWAY HALLMARK_REACTIVE_OXYGEN_SPECIES_PATHWAY 17/664 49/3619 0.0045726131840628 0.0326615227433057 0.0288796622151335 MPO/LSP1/GLRX/FTL/PRNP/PRDX1/PRDX4/LAMTOR5/TXN/CAT/PRDX2/NDUFS2/GCLC/HMOX2/SOD1/MGST1/TXNRD1 17
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ID Description GeneRatio BgRatio pvalue p.adjust qvalue geneID Count
HALLMARK_CHOLESTEROL_HOMEOSTASIS HALLMARK_CHOLESTEROL_HOMEOSTASIS 34/485 66/3619 8.05528863999684e-14 4.02764431999842e-12 2.7981528959989e-12 HMGCS1/SQLE/LDLR/HMGCR/FDFT1/ACAT2/LSS/MVD/SCD/IDI1/MVK/TM7SF2/CD9/SREBF2/CYP51A1/FDPS/FADS2/STARD4/DHCR7/HSD17B7/ALDOC/TMEM97/FASN/ANTXR2/PCYT2/NSDHL/SC5D/EBP/GNAI1/CLU/ACSS2/TNFRSF12A/CXCL16/AVPR1A 34
HALLMARK_TNFA_SIGNALING_VIA_NFKB HALLMARK_TNFA_SIGNALING_VIA_NFKB 50/485 179/3619 1.01402471870691e-07 2.53506179676728e-06 1.7612008272278e-06 LDLR/NR4A1/EGR3/PPP1R15A/CSF1/ID2/CD44/LAMB3/PHLDA2/PTGS2/KLF6/SQSTM1/CDKN1A/CCL5/PTGER4/SLC2A3/SPHK1/BHLHE40/SDC4/LIF/EGR1/TRIB1/CCND1/SLC2A6/KLF10/RELB/NR4A2/INHBA/GEM/PTPRE/SERPINE1/MXD1/SOCS3/MCL1/TRAF1/DUSP5/SOD2/PHLDA1/GPR183/PMEPA1/MAFF/NFKB2/FOSL1/STAT5A/ZC3H12A/CCL2/MAP2K3/KLF4/IER3/CXCL2 50
HALLMARK_IL2_STAT5_SIGNALING HALLMARK_IL2_STAT5_SIGNALING 48/485 175/3619 3.42330923788095e-07 5.70551539646826e-06 3.96383174912532e-06 PLEC/NCS1/ECM1/IL1RL1/CSF1/CD44/SLC29A2/EMP1/TNFRSF18/HOPX/AHR/PIM1/KLF6/SPP1/SLC2A3/IL4R/AHNAK/BHLHE40/LIF/CDC6/CDCP1/CDKN1C/TNFRSF4/IL18R1/IL10RA/COL6A1/NRP1/IL2RB/MYO1C/NT5E/PLIN2/MXD1/SPRY4/CAPG/TRAF1/GSTO1/NFKBIZ/NDRG1/PNP/PHLDA1/SOCS2/CYFIP1/LTB/MAFF/IL2RA/CAPN3/CCND3/CISH 48
HALLMARK_EPITHELIAL_MESENCHYMAL_TRANSITION HALLMARK_EPITHELIAL_MESENCHYMAL_TRANSITION 42/485 147/3619 5.86959048681588e-07 7.33698810851986e-06 5.09727594907695e-06 ECM1/LGALS1/GPC1/VIM/ID2/TIMP3/CD44/MMP14/ITGB5/ELN/TIMP1/PRSS2/SPP1/LRP1/SDC4/FLNA/SFRP4/SCG2/THBS1/INHBA/GEM/NT5E/TNFRSF12A/SERPINE1/CXCL8/VCAN/CAPG/COL6A2/TGFB1/DAB2/SPARC/PMP22/HTRA1/EMP3/PMEPA1/GJA1/ACTA2/IGFBP2/PDLIM4/MCM7/COL7A1/ITGB3 42
HALLMARK_COAGULATION HALLMARK_COAGULATION 28/485 90/3619 8.19189058332695e-06 8.19189058332695e-05 5.69120819473241e-05 CD9/GSN/CAPN2/PROS1/TIMP3/MMP14/ANXA1/DUSP6/VWF/PRSS23/TIMP1/LRP1/CLU/CRIP2/THBS1/RAPGEF3/SERPINE1/DUSP14/MMP7/SPARC/WDR1/HTRA1/MAFF/PEF1/PLAT/THBD/ITGB3/CTSO 28
HALLMARK_INFLAMMATORY_RESPONSE HALLMARK_INFLAMMATORY_RESPONSE 37/485 146/3619 5.59573011202946e-05 0.000466310842669122 0.00032396332227539 LDLR/CSF1/MMP14/STAB1/SEMA4D/AHR/TIMP1/KLF6/CDKN1A/CCL5/PTGER4/IL4R/SPHK1/C3AR1/LIF/C5AR1/IL18R1/IL10RA/DCBLD2/RGS1/CD55/INHBA/IL2RB/AXL/PTPRE/SERPINE1/CXCL8/MXD1/PTGIR/LCP2/ADORA2B/IRF7/GPR183/EMP3/EREG/CCL2/ITGB3 37
HALLMARK_MYOGENESIS HALLMARK_MYOGENESIS 34/485 139/3619 0.000236748530913395 0.00169106093509568 0.00117484233385595 SCD/CD36/FDPS/GSN/KIFC3/ITGB5/LPIN1/PTP4A3/CDKN1A/CAMK2B/CLU/SPHK1/BHLHE40/CNN3/HDAC5/AEBP1/MYO1C/CACNA1H/PLXNB2/COL6A2/TGFB1/DMPK/SPARC/MEF2D/PDLIM7/AGRN/BAG1/ITGA7/EFS/MYH11/MYH9/EPHB3/MEF2A/PYGM 34
HALLMARK_APOPTOSIS HALLMARK_APOPTOSIS 34/485 145/3619 0.000552210136173434 0.00345131335108396 0.0023977545386478 GSN/LMNA/EGR3/TXNIP/TIMP3/CD44/ANXA1/CCNA1/EMP1/SC5D/EBP/TIMP1/SLC20A1/BMF/SQSTM1/CDKN1A/CLU/DDIT3/CASP2/CCND1/GPX1/HGF/KRT18/TNFRSF12A/MCL1/PEA15/PTK2/SOD2/EREG/AVPR1A/ERBB2/PLAT/IER3/HSPB1 34
HALLMARK_ANDROGEN_RESPONSE HALLMARK_ANDROGEN_RESPONSE 23/485 92/3619 0.00175936919875606 0.0090260218179231 0.0062707098945571 HMGCS1/INSIG1/HMGCR/DHCR24/SCD/IDI1/FADS1/ABHD2/PTK2B/GUCY1A1/CCND1/KRT8/CDK6/ELL2/ARID5B/ACSL3/NDRG1/ZMIZ1/KRT19/AKAP12/PMEPA1/ELOVL5/CCND3 23
HALLMARK_MTORC1_SIGNALING HALLMARK_MTORC1_SIGNALING 41/485 196/3619 0.00180520436358462 0.0090260218179231 0.0062707098945571 HMGCS1/INSIG1/SQLE/LDLR/HMGCR/DHCR24/SCD/IDI1/TM7SF2/CD9/CYP51A1/FADS2/STARD4/DHCR7/FADS1/PPP1R15A/TMEM97/SLA/SC5D/EBP/SQSTM1/CDKN1A/SLC2A3/BHLHE40/RDH11/DDIT3/ACACA/ACLY/ELOVL6/CYB5B/ENO1/IDH1/ACSL3/MCM4/PNP/ADIPOR2/YKT6/RRM2/ELOVL5/MAP2K3/UNG 41
HALLMARK_KRAS_SIGNALING_UP HALLMARK_KRAS_SIGNALING_UP 31/485 140/3619 0.0025814204565396 0.0117337293479073 0.00815185407328295 VWA5A/PPP1R15A/ID2/ACE/EMP1/DUSP6/PTGS2/SPP1/GUCY1A1/TMEM158/LAPTM5/LAT2/C3AR1/LIF/TRIB1/IL10RA/KCNN4/PCSK1N/DCBLD2/NRP1/ADAM8/INHBA/WNT7A/TRAF1/F13A1/JUP/AKAP12/MYCN/EREG/PLAT/KLF4 31
HALLMARK_ESTROGEN_RESPONSE_EARLY HALLMARK_ESTROGEN_RESPONSE_EARLY 34/485 161/3619 0.00372553431688764 0.0143429218799795 0.00996455625345946 FDFT1/DLC1/DHCR7/EGR3/FASN/CD44/TMEM164/ENDOD1/FHL2/PRSS23/ABHD2/KCNK5/BHLHE40/NRIP1/AQP3/CCND1/KRT8/KLF10/KRT18/CELSR1/MAST4/DHRS2/AR/SLC24A3/TTC39A/KRT19/ELF1/RET/GJA1/BAG1/ELOVL5/CISH/KLF4/SCARB1 34
HALLMARK_HYPOXIA HALLMARK_HYPOXIA 35/485 167/3619 0.00372915968879468 0.0143429218799795 0.00996455625345946 ANXA2/GPC1/CAVIN1/SLC25A1/PPP1R15A/ALDOC/PIM1/KLF6/CDKN1A/SLC2A3/BHLHE40/S100A4/SDC4/CDKN1C/DDIT3/CAVIN3/ENO1/SERPINE1/PLIN2/NDRG1/ADORA2B/TPST2/HS3ST1/DPYSL4/AKAP12/KDELR3/MAFF/HK1/MYH9/PFKP/KDM3A/WSB1/IER3/SCARB1/PYGM 35
HALLMARK_P53_PATHWAY HALLMARK_P53_PATHWAY 37/485 181/3619 0.00451185643134222 0.0161137729690793 0.0111948317469393 VWA5A/S100A10/TM4SF1/TXNIP/PPP1R15A/DGKA/CDKN1A/MDM2/SPHK1/S100A4/LIF/UPP1/ABHD4/DDIT3/RPS27L/TSPYL2/PLK3/STOM/PTPRE/ZBTB16/MXD1/PLXNB2/BAIAP2/XPC/PVT1/VDR/RALGDS/DDB2/TGFB1/NDRG1/PDGFA/ST14/CTSF/CCND3/PCNA/KLF4/IER3 37
HALLMARK_ESTROGEN_RESPONSE_LATE HALLMARK_ESTROGEN_RESPONSE_LATE 32/485 155/3619 0.00690125807123546 0.0230041935707849 0.0159818607965453 FDFT1/CD9/DHCR7/EGR3/ID2/CD44/MDK/CCNA1/PRSS23/ABHD2/PTPN6/KCNK5/TPSAB1/NAB2/NRIP1/CDC6/CCND1/DHRS2/GINS2/SLC24A3/KRT19/RET/DLG5/PLXNB1/ST14/BAG1/XRCC3/ELOVL5/CISH/LLGL2/KLF4/SCARB1 32
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ID Description GeneRatio BgRatio pvalue p.adjust qvalue geneID Count
HALLMARK_HEME_METABOLISM HALLMARK_HEME_METABOLISM 52/562 187/3619 7.50616949727036e-06 0.000375308474863518 0.000323950473040089 CTSB/ALAD/TENT5C/NNT/EPOR/KLF1/TFRC/LAMP2/ACP5/KLF3/TRIM58/BNIP3L/MARCHF8/GYPC/FECH/ALAS2/AHSP/SLC7A11/BLVRB/HEBP1/GYPE/IGSF3/SLC25A38/SEC14L1/FOXO3/SIDT2/TFDP2/BCAM/SELENBP1/ALDH6A1/CLCN3/CPOX/TOP1/GCLC/ABCG2/SLC2A1/BLVRA/CLIC2/DCAF10/PICALM/TMCC2/H4C3/XPO7/FN3K/SLC11A2/SLC66A2/TAL1/NFE2/HTRA2/MFHAS1/SLC6A9/MARCHF2 52
HALLMARK_INTERFERON_ALPHA_RESPONSE HALLMARK_INTERFERON_ALPHA_RESPONSE 29/562 93/3619 9.47028081952087e-05 0.00236757020488022 0.00204358691368608 SELL/PSMB9/B2M/TENT5A/EPSTI1/TAP1/SAMD9L/IFIT2/BST2/PSME1/TRIM26/HLA-C/IFIH1/SP110/UBE2L6/PSMB8/DDX60/IL7/CMPK2/EIF2AK2/PARP9/PROCR/CASP1/IFIT3/LPAR6/LAMP3/TRIM14/RIPK2/MX1 29
HALLMARK_INTERFERON_GAMMA_RESPONSE HALLMARK_INTERFERON_GAMMA_RESPONSE 47/562 183/3619 0.000182878622718431 0.00304797704530719 0.00263088544963357 CSF2RB/PSMB9/APOL6/B2M/CD38/EPSTI1/TAP1/HLA-A/TNFSF10/TNFAIP2/ITGB7/SERPING1/SELP/OAS2/OAS3/SAMD9L/IFIT2/CASP7/ICAM1/BST2/PSME1/TRIM26/HLA-B/IFIH1/SP110/AUTS2/IFIT1/UBE2L6/ISOC1/PSMB8/DDX60/IL7/CMPK2/VAMP8/EIF2AK2/GZMA/ST3GAL5/BANK1/CFH/CASP1/IFIT3/STAT4/TRIM14/RIPK2/IRF5/MX1/CASP4 47
HALLMARK_GLYCOLYSIS HALLMARK_GLYCOLYSIS 43/562 172/3619 0.000642828792818113 0.00803535991022641 0.00693578434356385 COL5A1/CXCR4/CHST2/RRAGD/PYGL/HK2/FKBP4/ALDH7A1/TALDO1/GUSB/B4GALT1/PAM/EXT2/GLRX/ERO1A/PLOD2/AGL/STC2/BIK/PKP2/GCLC/PLOD1/MERTK/P4HA1/LHPP/LDHA/GALK2/HS2ST1/ME2/MDH2/HAX1/CENPA/SAP30/GOT2/FUT8/DEPDC1/B4GALT4/FAM162A/RPE/GLCE/ALDH9A1/PGK1/VLDLR 43
paper_data/HSPC_LNPsRNA-HSPC_emptyLNPs-enr-h.all.v7.2.symbols-neg.txt
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ID Description GeneRatio BgRatio pvalue p.adjust qvalue geneID Count
paper_data/HSPC_LNPsRNA-HSPC_emptyLNPs-enr-h.all.v7.2.symbols-pos.txt
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42c6d9d3
ID Description GeneRatio BgRatio pvalue p.adjust qvalue geneID Count
HALLMARK_P53_PATHWAY HALLMARK_P53_PATHWAY 32/82 180/3589 1.17667615902607e-21 4.9420398679095e-20 4.21126204283015e-20 PHLDA3/CDKN1A/ZMAT3/FDXR/DDB2/AEN/RPS27L/MDM2/BAX/XPC/SESN1/BTG2/POLH/PLXNB2/GADD45A/IER5/CYFIP2/TRIAP1/PLK2/DRAM1/PPM1D/FAS/TM7SF3/EPHA2/PLK3/TNFSF9/SDC1/CCNG1/RETSAT/RNF19B/PRKAB1/TPRKB 32
HALLMARK_G2M_CHECKPOINT HALLMARK_G2M_CHECKPOINT 14/82 197/3589 0.000113483547035889 0.00238315448775367 0.00203075821011591 UBE2C/TOP2A/KPNA2/BUB1/AURKA/NEK2/CCNB2/HMMR/KIF2C/KIF20B/SMC4/CKS1B/SFPQ/TPX2 14
HALLMARK_APOPTOSIS HALLMARK_APOPTOSIS 11/82 145/3589 0.000378646878867755 0.00520840457313233 0.00443823948587718 CDKN1A/FDXR/BAX/BTG2/CD38/GADD45A/FAS/TOP2A/CCNA1/RETSAT/CD44 11
HALLMARK_E2F_TARGETS HALLMARK_E2F_TARGETS 13/82 200/3589 0.000496038530774508 0.00520840457313233 0.00443823948587718 CDKN1A/PPM1D/TOP2A/DEPDC1/KPNA2/AURKA/CCNB2/HMMR/KIF2C/SMC4/BUB1B/TUBB/CKS1B 13
paper_data/HSPC_UTelectro-HSPC_UT-enr-h.all.v7.2.symbols-neg.txt
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42c6d9d3
ID Description GeneRatio BgRatio pvalue p.adjust qvalue geneID Count
HALLMARK_E2F_TARGETS HALLMARK_E2F_TARGETS 94/628 200/3619 1.14415593949625e-23 5.72077969748125e-22 4.93793615993118e-22 LBR/TOP2A/BIRC5/H2AZ1/ESPL1/CENPM/DLGAP5/HMGB3/SPC24/STMN1/NCAPD2/KIF22/LMNB1/CIT/HMGB2/SPAG5/TCF19/CDCA8/CDCA3/SMC4/SSRP1/TACC3/ASF1B/MXD3/TIMELESS/CDKN2C/CCNB2/H2AX/DDX39A/AURKA/KIF4A/BUB1B/POLD1/CDC20/CDC25B/MCM3/PLK1/UBE2S/MYBL2/SHMT1/NAA38/RANBP1/MYC/GINS1/KIF2C/XRCC6/AURKB/CENPE/KIF18B/ANP32E/TBRG4/MCM7/KPNA2/NUP205/HMMR/TFRC/CCP110/RACGAP1/PTTG1/LIG1/RAN/MAD2L1/SPC25/NME1/SUV39H1/TK1/MELK/PRDX4/E2F8/TUBB/JPT1/DUT/TRA2B/POP7/MCM2/CDKN1B/ILF3/SNRPB/WEE1/CDC25A/WDR90/SMC1A/RAD51AP1/DEPDC1/UNG/HNRNPD/RFC2/LYAR/CNOT9/CDKN3/MKI67/TMPO/POLE4/EED 94
HALLMARK_G2M_CHECKPOINT HALLMARK_G2M_CHECKPOINT 79/628 197/3619 6.05671314925589e-15 1.51417828731397e-13 1.30697494273417e-13 LBR/TPX2/TOP2A/MARCKS/BIRC5/H2AZ1/ESPL1/HMGB3/STMN1/CCNF/KIF22/LMNB1/H2AZ2/SFPQ/TFDP1/SMC4/TACC3/DTYMK/TROAP/CDKN2C/CCNB2/H2AX/KIF23/KIF11/DDX39A/CENPF/AURKA/KIF4A/CDC20/CDC25B/BUB1/INCENP/MCM3/PLK1/UBE2S/MYBL2/MYC/KIF2C/RAD54L/AURKB/CENPE/CENPA/CCNA2/KPNA2/HMMR/RACGAP1/PTTG1/NUP50/KMT5A/KIF15/TTK/MAD2L1/NSD2/AMD1/UBE2C/E2F2/SUV39H1/NDC80/HMGN2/UCK2/JPT1/TRA2B/ODF2/MCM2/CDKN1B/ILF3/DBF4/PBK/CDC25A/NEK2/TOP1/SMC1A/KPNB1/HNRNPD/E2F4/CDKN3/MKI67/TMPO/PML 79
HALLMARK_MTORC1_SIGNALING HALLMARK_MTORC1_SIGNALING 54/628 196/3619 0.000170187120256483 0.00283645200427471 0.00244830594053186 CXCR4/PHGDH/CALR/CCNF/PGM1/PGK1/ELOVL6/CORO1A/HSPA5/ITGB2/DDX39A/AURKA/PPA1/SLC37A4/TUBA4A/BUB1/PLK1/IDH1/DHFR/GPI/SDF2L1/ADD3/NUP205/RPN1/TFRC/SLC1A4/TPI1/ATP5MC1/TXNRD1/TOMM40/PFKL/TES/PSMB5/HSP90B1/DHCR24/SHMT2/NIBAN1/PIK3R3/GBE1/INSIG1/MCM2/GLA/CDC25A/CTSC/PRDX1/PPIA/G6PD/SLC9A3R1/GSR/SCD/UNG/EBP/LGMN/LDHA 54
HALLMARK_MYC_TARGETS_V1 HALLMARK_MYC_TARGETS_V1 51/628 200/3619 0.00181352862240902 0.0226691077801128 0.0195670193470447 H2AZ1/HNRNPA2B1/GOT2/TUFM/PGK1/TFDP1/PPM1G/POLE3/CDC20/RUVBL2/PSMA7/RANBP1/MYC/XRCC6/CDK2/C1QBP/MCM7/CCNA2/KPNA2/SNRPA/HDGF/TXNL4A/STARD7/RAN/MAD2L1/PSMB3/TYMS/NME1/RRM1/MRPL23/HNRNPA3/PRDX4/NHP2/CYC1/PHB/DUT/TRA2B/MCM2/SRSF7/CCT5/ILF2/PPIA/RPS5/KPNB1/SRPK1/HNRNPD/PABPC4/SNRPD2/YWHAQ/LDHA/SNRPA1 51
HALLMARK_ADIPOGENESIS HALLMARK_ADIPOGENESIS 45/628 179/3619 0.00445492703086528 0.0373212072083484 0.0322140946429955 TALDO1/TST/PGM1/PTGER3/ELOVL6/AIFM1/CDKN2C/HADH/UQCRC1/IDH1/MDH2/APOE/CPT2/RTN3/VEGFB/ACADS/AGPAT3/SLC25A10/CAT/SLC19A1/MYLK/PFKL/ITSN1/ECHS1/PREB/GHITM/NDUFS3/UCK1/CYC1/GBE1/DHRS7/DLAT/ATP1B3/COQ3/UQCRQ/COX8A/SLC5A6/FAH/TKT/ECH1/NDUFB7/PDCD4/COQ9/ACO2/CS 45
HALLMARK_OXIDATIVE_PHOSPHORYLATION HALLMARK_OXIDATIVE_PHOSPHORYLATION 49/628 199/3619 0.00476367136442308 0.0373212072083484 0.0322140946429955 IDH2/GOT2/NNT/SLC25A5/AIFM1/UQCRC1/HADHA/MRPS15/NDUFV1/MRPL11/ACAA1/NDUFA2/IDH1/GPI/OAT/MDH2/IDH3B/PMPCA/ETFA/ACAT1/ETFDH/POLR2F/ATP5MC1/TIMM13/NDUFS7/ECHS1/NDUFS8/ATP5F1A/NDUFS3/TIMM50/MPC1/CYC1/COX7C/DLAT/UQCRQ/COX8A/ECI1/ACADSB/ATP5F1B/ATP5MC3/ECH1/NDUFB7/ALDH6A1/MRPS12/FDX1/TIMM10/LDHA/ACO2/CS 49
HALLMARK_MITOTIC_SPINDLE HALLMARK_MITOTIC_SPINDLE 48/628 195/3619 0.00522496900916878 0.0373212072083484 0.0322140946429955 TPX2/TOP2A/MARCKS/BIRC5/ESPL1/DLGAP5/KIF22/LMNB1/MID1IP1/SMC4/EPB41/CCNB2/KIF23/KIF11/CENPF/AURKA/KIF4A/TUBA4A/PREX1/BUB1/INCENP/PIF1/PLK1/SAC3D1/KIF2C/KPTN/ALS2/SUN2/CENPE/KATNB1/RACGAP1/KIF15/TTK/CDK5RAP2/GEMIN4/CKAP5/ITSN1/NDC80/CNTROB/ANLN/RALBP1/ECT2/RASA2/HDAC6/NEK2/SMC1A/ARHGAP4/EPB41L2 48
paper_data/HSPC_UTelectro-HSPC_UT-enr-h.all.v7.2.symbols-pos.txt
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ID Description GeneRatio BgRatio pvalue p.adjust qvalue geneID Count
HALLMARK_EPITHELIAL_MESENCHYMAL_TRANSITION HALLMARK_EPITHELIAL_MESENCHYMAL_TRANSITION 54/476 147/3619 1.01756398926306e-13 4.98606354738898e-12 3.10624796722407e-12 VIM/ECM1/LGALS1/CD44/TIMP3/MMP14/ID2/ELN/THBS1/LRP1/TIMP1/JUN/ITGB5/CXCL8/DAB2/ITGB3/SDC4/SPP1/TPM4/PMP22/SFRP4/SERPINE1/INHBA/PRSS2/GADD45A/CAPG/ACTA2/SCG2/GPC1/TNFRSF12A/FLNA/SDC1/NT5E/SPARC/RHOB/GEM/PDLIM4/GJA1/EMP3/VEGFA/ENO2/PMEPA1/VCAN/TGFB1/COL7A1/LAMA3/PDGFRB/CTHRC1/MMP2/HTRA1/ITGA5/TNFAIP3/COL6A2/SLC6A8 54
HALLMARK_TNFA_SIGNALING_VIA_NFKB HALLMARK_TNFA_SIGNALING_VIA_NFKB 59/476 179/3619 1.61042258484281e-12 3.94553533286487e-11 2.4580134189706e-11 CDKN1A/CSF1/PPP1R15A/NR4A1/CD44/SLC2A3/LAMB3/EGR3/ID2/SQSTM1/LIF/JUN/PHLDA2/SPHK1/PTGS2/RELB/SDC4/CCL5/NR4A2/SERPINE1/TRAF1/INHBA/PTGER4/FOSL1/BHLHE40/CCND1/TRIP10/SOCS3/GADD45A/MAFF/ABCA1/KLF6/BTG2/RHOB/CCL2/STAT5A/NR4A3/GEM/DUSP5/NFKB2/JAG1/SMAD3/ATF3/LDLR/VEGFA/NFAT5/EGR2/CXCL3/PMEPA1/IER5/CD69/ATP2B1/ETS2/ZFP36/KLF10/TGIF1/TNFAIP3/PHLDA1/SOD2 59
HALLMARK_INFLAMMATORY_RESPONSE HALLMARK_INFLAMMATORY_RESPONSE 47/476 146/3619 9.0158533982279e-10 1.47258938837722e-08 9.17402626486347e-09 CDKN1A/CSF1/STAB1/MMP14/AHR/IL4R/LIF/TIMP1/AXL/CD55/SPHK1/CXCL8/SEMA4D/RGS1/IL18R1/ITGB3/CCL5/IL10RA/SCN1B/SERPINE1/INHBA/PTGER4/C5AR1/ABCA1/ADORA2B/LYN/KLF6/EREG/BTG2/CCL2/PTGIR/LDLR/EMP3/C3AR1/LCP2/CD69/ATP2B1/CCR7/P2RX7/GPR132/HIF1A/CD70/ITGA5/P2RX4/GABBR1/CD40/SCARF1 47
HALLMARK_IL2_STAT5_SIGNALING HALLMARK_IL2_STAT5_SIGNALING 50/476 175/3619 2.41388968589722e-08 2.95701486522409e-07 1.8421789708163e-07 PLEC/NCS1/ECM1/IL1RL1/CSF1/CD44/SLC2A3/AHR/IL4R/HOPX/PLIN2/EMP1/TNFRSF18/LIF/AHNAK/CDKN1C/PIM1/MYO1C/CDCP1/IL18R1/SPP1/ANXA4/IL10RA/IL2RA/TNFRSF4/TRAF1/BHLHE40/CAPG/MAFF/KLF6/CKAP4/NT5E/RHOB/NCOA3/NRP1/CYFIP1/BATF3/GSTO1/HUWE1/NFKBIZ/CA2/BMPR2/NDRG1/SOCS1/CAPN3/MYO1E/PHLDA1/F2RL2/P2RX4/GUCY1B1 50
HALLMARK_P53_PATHWAY HALLMARK_P53_PATHWAY 48/476 181/3619 5.77260536896805e-07 5.65715326158869e-06 3.5243274884226e-06 VWA5A/S100A10/CDKN1A/PPP1R15A/TM4SF1/PHLDA3/LIF/DDIT4/JUN/SPHK1/MDM2/DDIT3/DGKA/XPC/PDGFA/RPS27L/S100A4/TSPYL2/ABHD4/GADD45A/UPP1/VDR/EPHA2/ZBTB16/SLC3A2/STOM/ZMAT3/AEN/SDC1/FDXR/BTG2/DDB2/PTPN14/PITPNC1/PLK3/ATF3/PLXNB2/IER5/HMOX1/TGFB1/ITGB4/PVT1/NDRG1/CDKN2A/SOCS1/ST14/CTSF/TXNIP 48
HALLMARK_COAGULATION HALLMARK_COAGULATION 29/476 90/3619 1.72090411137264e-06 1.40540502428766e-05 8.75547705786081e-06 CD9/CAPN2/GSN/TIMP3/PROS1/VWF/MMP14/THBS1/PRSS23/LRP1/TIMP1/ANXA1/ITGB3/CRIP2/DUSP6/SERPINE1/CLU/RAPGEF3/MAFF/SPARC/MMP7/CTSH/DUSP14/WDR1/MMP2/HTRA1/C3/F2RL2/CTSO 29
HALLMARK_APOPTOSIS HALLMARK_APOPTOSIS 39/476 145/3619 4.86110579568721e-06 3.40277405698105e-05 2.11988072293126e-05 CDKN1A/GSN/CD44/LMNA/TIMP3/EGR3/BMF/EMP1/SQSTM1/TIMP1/JUN/CCNA1/ANXA1/GPX1/DDIT3/PTK2/CLU/CCND1/H1-0/GADD45A/KRT18/TNFRSF12A/EREG/FDXR/BTG2/RHOB/ISG20/ATF3/ENO2/SLC20A1/HMOX1/CASP8/CD69/PDGFRB/MMP2/HGF/AVPR1A/SOD2/TXNIP 39
HALLMARK_KRAS_SIGNALING_UP HALLMARK_KRAS_SIGNALING_UP 37/476 140/3619 1.33324123203971e-05 8.1661025462432e-05 5.08736785909888e-05 VWA5A/PPP1R15A/ACE/ID2/EMP1/LAT2/LIF/LAPTM5/PTGS2/ST6GAL1/GUCY1A1/SPP1/PCSK1N/DUSP6/IL10RA/ADAM8/SCN1B/TRAF1/INHBA/TMEM158/EREG/TFPI/NRP1/F13A1/CCSER2/C3AR1/DNMBP/WNT7A/USP12/KCNN4/AKAP12/CA2/MYCN/PPBP/TNFAIP3/ADGRA2/GNG11 37
HALLMARK_HYPOXIA HALLMARK_HYPOXIA 41/476 167/3619 3.12755038533088e-05 0.000170277743201348 0.000106080656344556 ANXA2/CDKN1A/PPP1R15A/SLC2A3/CAVIN1/PLIN2/DDIT4/JUN/CDKN1C/PIM1/DDIT3/SDC4/HS3ST1/SERPINE1/BHLHE40/S100A4/CAVIN3/TPST2/MAFF/GPC1/ADORA2B/KLF6/ISG20/P4HA2/LXN/ATF3/HK1/VEGFA/MXI1/PFKP/ENO2/CHST3/HMOX1/PRKCA/AKAP12/MYH9/NDRG1/ZFP36/IDS/TNFAIP3/KDM3A 41
HALLMARK_UV_RESPONSE_DN HALLMARK_UV_RESPONSE_DN 32/476 124/3619 8.59290198653054e-05 0.000421052197339997 0.000262309639588827 ANXA2/DLC1/FHL2/PTPRM/DAB2/CELF2/ITGB3/PMP22/ANXA4/SERPINE1/BHLHE40/SYNJ2/MAP1B/TGFBR2/ADORA2B/SLC22A18/TFPI/MGLL/NRP1/ZMIZ1/SMAD3/NEK7/GJA1/LDLR/MAGI2/RBPMS/ATXN1/PRKCA/ATP2B1/PDGFRB/AKT3/CDC42BPA 32
HALLMARK_IL6_JAK_STAT3_SIGNALING HALLMARK_IL6_JAK_STAT3_SIGNALING 19/476 67/3619 0.00069003907615012 0.00307381043012326 0.00191494097687593 CD9/CSF1/CD36/CD44/IL4R/JUN/PIM1/IL18R1/ITGB3/STAT3/IL2RA/SOCS3/LEPR/TNFRSF12A/PTPN11/CXCL3/HMOX1/TGFB1/SOCS1 19
HALLMARK_TGF_BETA_SIGNALING HALLMARK_TGF_BETA_SIGNALING 15/476 51/3619 0.00166683284665336 0.00680623412383456 0.00424018882043399 PPP1R15A/ID2/THBS1/CDKN1C/SKIL/SERPINE1/RAB31/SMAD3/NOG/SLC20A1/PMEPA1/TGFB1/BMPR2/KLF10/TGIF1 15
HALLMARK_ALLOGRAFT_REJECTION HALLMARK_ALLOGRAFT_REJECTION 34/476 161/3619 0.00272857020457278 0.010284610771082 0.00640716890142596 CSF1/GBP2/STAB1/IL4R/LIF/TIMP1/GZMB/CCL5/PTPN6/IL2RA/INHBA/CXCR3/CAPG/FLNA/LYN/FGR/HLA-E/EREG/CCL2/HLA-DOA/KRT1/PTPRC/GALNT1/TGFB1/LCP2/ELF4/TLR6/CDKN2A/EIF3D/SOCS1/HIF1A/CD4/CD40/HCLS1 34
HALLMARK_ANGIOGENESIS HALLMARK_ANGIOGENESIS 9/476 26/3619 0.00429468168935447 0.0150313859127406 0.00936434353317892 TIMP1/PTK2/SPP1/PDGFA/S100A4/NRP1/JAG1/VEGFA/VCAN 9
HALLMARK_HEDGEHOG_SIGNALING HALLMARK_HEDGEHOG_SIGNALING 9/476 27/3619 0.00570893779976947 0.0186491968125803 0.0116181892065484 HEY1/CELSR1/SCG2/RASA1/NRP2/NRP1/VEGFA/MYH9/ETS2 9
HALLMARK_MYOGENESIS HALLMARK_MYOGENESIS 29/476 139/3619 0.00655897080452823 0.0200868480888677 0.0125138258770604 CDKN1A/CD36/GSN/PTP4A3/LPIN1/KIFC3/SPHK1/ITGB5/HDAC5/MYO1C/CAMK2B/CLU/ABLIM1/BHLHE40/SPARC/MEF2A/PTGIS/ITGA7/PLXNB2/TGFB1/ITGB4/AEBP1/DMPK/MYH3/CACNA1H/MYH9/COL6A2/SLC6A8/MEF2D 29
HALLMARK_ESTROGEN_RESPONSE_EARLY HALLMARK_ESTROGEN_RESPONSE_EARLY 32/476 161/3619 0.00931106713470552 0.026350143716326 0.0164157715955629 DLC1/CD44/EGR3/PRSS23/ENDOD1/ABHD2/FHL2/KRT8/NRIP1/MAST4/AQP3/RPS6KA2/ABLIM1/TMEM164/BHLHE40/CCND1/CELSR1/RAB31/DHRS2/KRT18/ELF1/MED13L/SLC24A3/GJA1/TTC39A/AR/FLNB/RET/SLC27A2/KCNK5/KLF10/CLDN7 32
HALLMARK_APICAL_JUNCTION HALLMARK_APICAL_JUNCTION 30/476 149/3619 0.00967964463048709 0.026350143716326 0.0164157715955629 ITGA3/CD34/CD276/LAMB3/VWF/VCL/MDK/GNAI1/PTK2/ICAM5/TRAF1/RASA1/CAP1/ACTG1/RRAS/FLNC/THBS3/ZYX/PTPRC/CTNNA1/VCAN/ITGB4/LAMA3/MMP2/PLCG1/SRC/MYH9/ITGA9/AKT3/CLDN7 30
paper_data/HSPC_electroRNA-HSPC_UT-enr-h.all.v7.2.symbols-neg.txt
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42c6d9d3
ID Description GeneRatio BgRatio pvalue p.adjust qvalue geneID Count
HALLMARK_E2F_TARGETS HALLMARK_E2F_TARGETS 95/742 200/3686 2.68571394430656e-19 1.34285697215328e-17 1.07428557772262e-17 LBR/H2AZ1/TCF19/UNG/STMN1/DLGAP5/ESPL1/SSRP1/SPC24/MYBL2/ASF1B/CENPM/MCM3/RANBP1/LMNB1/NAA38/UBE2S/ANP32E/GINS1/BIRC5/CDCA3/DDX39A/HMGB3/XRCC6/CDKN2C/SHMT1/MYC/TFRC/KIF22/MCM4/CCNE1/MXD3/TIMELESS/TBRG4/PRPS1/CENPE/POP7/EZH2/PRDX4/MCM7/MELK/RBBP7/RAN/POLD1/NOLC1/E2F8/DUT/RRM2/H2AX/SMC6/HNRNPD/TK1/NOP56/SPAG5/MSH2/NUP205/HMGB2/MCM2/SNRPB/LYAR/POLD3/AURKB/CDKN1B/CDK4/AK2/CCP110/RFC2/NME1/NASP/SPC25/CTCF/ILF3/TRA2B/MAD2L1/CNOT9/POLE4/HELLS/SMC1A/KIF4A/CDCA8/DCLRE1B/BUB1B/DCTPP1/CDC25A/UBE2T/UBR7/SUV39H1/PRIM2/KIF18B/WDR90/TMPO/DONSON/SRSF2/RAD51AP1/PHF5A 95
HALLMARK_OXIDATIVE_PHOSPHORYLATION HALLMARK_OXIDATIVE_PHOSPHORYLATION 85/742 199/3686 6.68232719850458e-14 1.67058179962615e-12 1.33646543970092e-12 IDH2/GOT2/SLC25A5/IDH1/MRPS15/PMPCA/UQCRC1/IDH3B/MRPL11/COX11/ATP5MC1/GPI/HADHA/ACAT1/MPC1/AIFM1/TIMM50/OAT/NDUFA3/COX7C/NDUFV1/COX6A1/NDUFS3/LDHA/ATP5F1A/FH/UQCRQ/MDH2/ACAA1/ECHS1/ACADSB/DLAT/PRDX3/NNT/POLR2F/NDUFS8/CS/MRPS22/MRPS12/HSPA9/NDUFA4/NDUFA2/ETFA/ATP1B1/HSD17B10/DLD/NDUFS2/TIMM13/PDHA1/HTRA2/MRPL34/ATP5F1B/ETFDH/NDUFS6/NDUFA6/ALDH6A1/ATP5MC3/ECH1/COX7B/NDUFB7/ACAA2/NDUFAB1/NDUFS7/SUCLG1/ATP5ME/ATP5PD/NDUFB2/TIMM10/COX8A/ATP5F1D/ECI1/CYB5A/CYC1/AFG3L2/DLST/IMMT/UQCRH/VDAC3/COX5B/MRPS11/NDUFA8/NDUFS1/NDUFA1/COX4I1/RHOT2 85
HALLMARK_MYC_TARGETS_V1 HALLMARK_MYC_TARGETS_V1 70/742 200/3686 3.18939392905253e-07 5.31565654842088e-06 4.2525252387367e-06 H2AZ1/GOT2/TUFM/HNRNPA2B1/TFDP1/PPM1G/RANBP1/POLE3/PSMB3/TXNL4A/PGK1/XRCC6/CDK2/MYC/C1QBP/MCM4/SRSF7/PSMA7/RUVBL2/SNRPA/SNRPA1/PRDX4/MCM7/LDHA/STARD7/KPNB1/RAN/NHP2/NOLC1/CCT5/PRDX3/DUT/FBL/HNRNPD/PPIA/YWHAQ/RRM1/NOP56/PHB/HNRNPC/MCM2/ILF2/PRPF31/SNRPD2/PSMA4/CDK4/DHX15/SNRPG/LSM7/NDUFAB1/NME1/SNRPD3/RPS5/ERH/HNRNPA3/CYC1/PABPC4/TRA2B/MAD2L1/MRPL23/SRPK1/XPOT/EIF3B/VDAC3/HDGF/EEF1B2/AP3S1/PSMB2/YWHAE/SRSF2 70
HALLMARK_ADIPOGENESIS HALLMARK_ADIPOGENESIS 61/742 180/3686 6.45649179425095e-06 8.07061474281369e-05 6.45649179425095e-05 TALDO1/PGM1/TST/ELOVL6/RTN3/IDH1/UQCRC1/HADH/APOE/SLC5A6/CDKN2C/SLC25A10/PTGER3/AIFM1/CAT/COX6A1/NDUFS3/COQ3/UCK1/UQCRQ/MDH2/ECHS1/DLAT/PRDX3/ACADS/ATP1B3/SLC1A5/CS/MIGA2/DLD/SAMM50/VEGFB/SOD1/PDCD4/GHITM/AK2/FAH/SLC19A1/ECH1/COX7B/NDUFB7/ACAA2/PPP1R15B/NDUFAB1/SUCLG1/PREB/COX8A/ARL4A/MTCH2/CYC1/CHCHD10/IMMT/ITSN1/CPT2/ESRRA/AGPAT3/SLC25A1/PFKL/COQ9/CRAT/DHRS7 61
HALLMARK_MTORC1_SIGNALING HALLMARK_MTORC1_SIGNALING 63/742 196/3686 3.08792816551769e-05 0.000308792816551769 0.000247034253241415 PHGDH/UNG/PGM1/CALR/ELOVL6/SLC37A4/CXCR4/IDH1/ITGB2/PPA1/CTSC/DDX39A/CORO1A/PGK1/HSPA5/TUBA4A/ATP5MC1/SDF2L1/NIBAN1/GPI/TFRC/MCM4/PIK3R3/TPI1/GLA/LDHA/TES/TOMM40/HMBS/ADD3/SHMT2/RRM2/DHFR/TXNRD1/SLC1A5/PPIA/SCD/HSPA9/DHCR24/GLRX/PSMB5/INSIG1/PSME3/NUP205/MCM2/PSMG1/RPN1/PSMA4/CCNF/ERO1A/ARPC5L/GSR/HK2/IMMT/PRDX1/PFKL/CDC25A/LGMN/EBP/PSAT1/SSR1/TMEM97/HSP90B1 63
HALLMARK_G2M_CHECKPOINT HALLMARK_G2M_CHECKPOINT 62/742 197/3686 7.2748496198563e-05 0.000606237468321358 0.000484989974657087 LBR/H2AZ1/MARCKS/STMN1/ESPL1/H2AZ2/MYBL2/MCM3/TFDP1/LMNB1/UBE2S/BIRC5/DDX39A/HMGB3/AMD1/CDKN2C/MYC/TPX2/KIF22/SFPQ/FBXO5/UCK2/CENPE/DTYMK/EZH2/KPNB1/HMGN2/NOLC1/CDC7/H2AX/RAD54L/HNRNPD/NCL/MCM2/AURKB/CDKN1B/NUP50/CDK4/E2F2/KIF15/CCNF/CBX1/NASP/CTCF/ILF3/E2F4/TRA2B/ATF5/MAD2L1/NSD2/KIF11/GINS2/E2F1/SMC1A/KIF4A/KIF23/CHMP1A/CDC25A/SUV39H1/PRIM2/TMPO/SRSF2 62
HALLMARK_HEME_METABOLISM HALLMARK_HEME_METABOLISM 56/742 187/3686 0.000676277812638628 0.00483055580456163 0.0038644446436493 ALAD/KLF1/TENT5C/EPB41/FECH/PRDX2/TRIM58/TFDP2/AHSP/BLVRB/PC/CTSB/SELENBP1/KEL/BNIP3L/EPOR/ALAS2/TFRC/CAT/NARF/HBB/NFE2/GYPC/PPOX/FN3K/BCAM/SLC25A38/GDE1/HMBS/RNF123/NNT/PIGQ/HBQ1/MARCHF8/KLF3/GLRX5/DCAF11/HTRA2/HEBP1/EPB42/SLC66A2/GYPE/ALDH6A1/E2F2/LAMP2/TAL1/ADD1/EIF2AK1/BPGM/H4C3/TMCC2/ACP5/HDGF/GATA1/BSG/ABCG2 56
HALLMARK_REACTIVE_OXYGEN_SPECIES_PATHWAY HALLMARK_REACTIVE_OXYGEN_SPECIES_PATHWAY 18/742 49/3686 0.0049913953053914 0.0311962206586963 0.024956976526957 MPO/PRDX2/MGST1/LSP1/CAT/PRDX4/TXNRD1/HMOX2/GLRX/NDUFS2/SOD1/NDUFA6/CDKN2D/GSR/TXN/PRDX1/PTPA/OXSR1 18
HALLMARK_FATTY_ACID_METABOLISM HALLMARK_FATTY_ACID_METABOLISM 40/742 138/3686 0.0072001951608787 0.0400010842271039 0.0320008673816831 ALDH1A1/ALAD/H2AZ1/ACSM3/ACSS1/GLUL/IDH1/HADH/IDH3B/PSME1/HSD17B4/HPGD/ECI2/ALDH9A1/GCDH/BPHL/LDHA/YWHAH/FH/ERP29/MDH2/ACAA1/ECHS1/ACADS/NCAPH2/DHCR24/HSD17B10/DLD/PDHA1/SMS/ETFDH/ECH1/ACAA2/NTHL1/SUCLG1/ECI1/DLST/CPT2/CRYZ/CRAT 40
paper_data/HSPC_electroRNA-HSPC_UT-enr-h.all.v7.2.symbols-pos.txt
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ID Description GeneRatio BgRatio pvalue p.adjust qvalue geneID Count
HALLMARK_TNFA_SIGNALING_VIA_NFKB HALLMARK_TNFA_SIGNALING_VIA_NFKB 70/591 182/3686 4.77644076206463e-14 2.34045597341167e-12 1.5083497143362e-12 CDKN1A/CSF1/CD44/NR4A1/PPP1R15A/GADD45A/SLC2A3/EGR3/IER5/LAMB3/BTG2/ID2/LIF/SQSTM1/JUN/PLK2/PTGS2/PTGER4/PHLDA2/RELB/TRAF1/FOSL1/SDC4/SPHK1/SERPINE1/INHBA/TNFSF9/CCL5/DRAM1/NR4A2/BHLHE40/CCND1/ATF3/RHOB/NFKB2/MAFF/LDLR/TRIP10/DUSP5/NFAT5/ABCA1/RNF19B/PTPRE/CD69/SMAD3/VEGFA/TNFAIP3/STAT5A/TGIF1/MXD1/PMEPA1/CCL2/GEM/PLAU/TNIP1/NR4A3/EGR1/ZFP36/CXCL2/EGR2/KLF6/MCL1/ATP2B1/SOCS3/JUNB/NFKBIA/CFLAR/EIF1/SPSB1/JAG1 70
HALLMARK_P53_PATHWAY HALLMARK_P53_PATHWAY 69/591 184/3686 3.19787317061324e-13 7.83478926800243e-12 5.04927342728406e-12 CDKN1A/PHLDA3/MDM2/FDXR/ZMAT3/RPS27L/VWA5A/DDB2/AEN/XPC/PPP1R15A/S100A10/PLXNB2/TM4SF1/GADD45A/BAX/DGKA/POLH/IER5/BTG2/SDC1/SESN1/PLK3/LIF/DDIT4/FAS/TRIAP1/JUN/PLK2/EPHA2/ABHD4/PTPN14/PPM1D/CYFIP2/SPHK1/PDGFA/TNFSF9/DRAM1/STOM/PVT1/ATF3/ZBTB16/ADA/DDIT3/NOTCH1/UPP1/TSPYL2/VDR/CCNG1/RNF19B/PTPRE/TGFB1/HMOX1/S100A4/SLC3A2/MXD1/ST14/ZFP36L1/ISCU/RGS16/EPS8L2/PITPNC1/NOL8/TOB1/CD82/RRAD/ANKRA2/SOCS1/KIF13B 69
HALLMARK_EPITHELIAL_MESENCHYMAL_TRANSITION HALLMARK_EPITHELIAL_MESENCHYMAL_TRANSITION 57/591 150/3686 2.36991514176042e-11 3.87086139820868e-10 2.49464751764254e-10 VIM/ECM1/CD44/MMP14/LGALS1/TIMP3/ACTA2/GADD45A/LRP1/THBS1/SDC1/ID2/ELN/GPC1/FAS/JUN/CXCL8/DAB2/TIMP1/ITGB5/SDC4/SPP1/SERPINE1/INHBA/TPM4/FLNA/ITGB3/CAPG/RHOB/SFRP4/PMP22/PRSS2/GJA1/SCG2/VEGFA/TGFB1/PDLIM4/NT5E/TNFAIP3/TNFRSF12A/PMEPA1/PDGFRB/HTRA1/FMOD/GEM/MMP2/COL6A2/LAMA3/LAMC1/WIPF1/VCAN/ENO2/SLC6A8/DST/SPARC/ITGA2/COL7A1 57
HALLMARK_INFLAMMATORY_RESPONSE HALLMARK_INFLAMMATORY_RESPONSE 53/591 155/3686 1.04749718821528e-08 1.28318405556371e-07 8.26971464380481e-08 CDKN1A/CSF1/MMP14/STAB1/IL4R/AHR/BTG2/LIF/CD55/PTGER4/SEMA4D/AXL/RGS1/CXCL8/TIMP1/SPHK1/IL18R1/SERPINE1/INHBA/CD70/TNFSF9/SCN1B/CCL5/IL10RA/ITGB3/C5AR1/LDLR/ABCA1/PTPRE/PTGIR/C3AR1/CD69/P2RX4/EBI3/CCR7/EREG/HIF1A/IL2RB/MXD1/LYN/CCL2/RGS16/KLF6/P2RX7/ADORA2B/GABBR1/ATP2B1/LCP2/NFKBIA/BEST1/CD82/ABI1/SCARF1 53
HALLMARK_IL2_STAT5_SIGNALING HALLMARK_IL2_STAT5_SIGNALING 56/591 179/3686 1.37850990185023e-07 1.35093970381322e-06 8.70637832747511e-07 PLEC/NCS1/CSF1/ECM1/CD44/IL1RL1/SLC2A3/IL4R/AHR/LIF/HOPX/PLIN2/EMP1/ANXA4/TNFRSF18/CDKN1C/CDCP1/AHNAK/TRAF1/PIM1/SPP1/IL18R1/IL10RA/BHLHE40/MYO1C/CAPG/RHOB/MAFF/IL2RA/HUWE1/NCOA3/CKAP4/PLSCR1/MYO1E/PLPP1/TNFRSF4/CAPN3/CYFIP1/P2RX4/NT5E/NFKBIZ/BCL2L1/NRP1/IL2RB/MXD1/F2RL2/BATF3/RGS16/KLF6/GUCY1B1/COL6A1/GBP4/PRKCH/SPRY4/SOCS1/BMPR2 56
HALLMARK_COAGULATION HALLMARK_COAGULATION 34/591 93/3686 8.86561600670357e-07 7.24025307214125e-06 4.66611368773872e-06 CD9/CAPN2/MMP14/TIMP3/GSN/VWF/PROS1/LRP1/THBS1/PRSS23/TIMP1/SERPINE1/ANXA1/DUSP6/CRIP2/ITGB3/RAPGEF3/MAFF/MMP7/CTSH/WDR1/F2RL2/PF4/C3/HTRA1/MMP2/PLAU/ISCU/CLU/SPARC/A2M/ITGA2/F8/DUSP14 34
HALLMARK_UV_RESPONSE_DN HALLMARK_UV_RESPONSE_DN 41/591 127/3686 2.93163687625689e-06 2.05214581337982e-05 1.32254295169484e-05 DLC1/ANXA2/FHL2/ANXA4/PTPRM/DAB2/CELF2/SCHIP1/SERPINE1/BHLHE40/ITGB3/SYNJ2/ZMIZ1/PMP22/LDLR/MAP1B/TGFBR2/SLC22A18/GJA1/SMAD3/TFPI/NRP1/ABCC1/ATXN1/CAV1/PDGFRB/PRKCA/RUNX1/CDC42BPA/LAMC1/MGLL/NEK7/PHF3/RBPMS/NIPBL/ADORA2B/AKT3/ATP2B1/ERBB2/SYNE1/MAGI2 41
HALLMARK_KRAS_SIGNALING_UP HALLMARK_KRAS_SIGNALING_UP 42/591 145/3686 4.49457545464877e-05 0.000275292746597237 0.000177417452157188 VWA5A/PPP1R15A/ACE/ID2/LIF/LAPTM5/EMP1/PTGS2/LAT2/TRAF1/SPP1/INHBA/SCN1B/IL10RA/DUSP6/ST6GAL1/CCSER2/PCSK1N/GUCY1A1/TMEM158/ADGRA2/WNT7A/AKAP12/C3AR1/ADAM8/TNFAIP3/TFPI/NRP1/EREG/PRDM1/PLAU/USP12/PPBP/DNMBP/JUP/RGS16/ZNF277/PLEK2/KCNN4/ITGA2/HDAC9/CBL 42
HALLMARK_APOPTOSIS HALLMARK_APOPTOSIS 42/591 148/3686 7.60567307805709e-05 0.000414086645360886 0.000266865722037091 CDKN1A/FDXR/LMNA/CD44/TIMP3/GSN/GADD45A/BAX/EGR3/CCNA1/BTG2/BMF/SQSTM1/GPX1/FAS/EMP1/JUN/TIMP1/PTK2/CD38/ANXA1/CCND1/ATF3/DDIT3/RHOB/KRT18/CD69/HMOX1/BCL2L1/TNFRSF12A/EREG/CAV1/PDGFRB/MMP2/SLC20A1/ENO2/CASP8/AVPR1A/CLU/MCL1/ERBB2/CFLAR 42
HALLMARK_IL6_JAK_STAT3_SIGNALING HALLMARK_IL6_JAK_STAT3_SIGNALING 24/591 71/3686 0.000156589496491878 0.000767288532810204 0.000494493146816458 CD9/CSF1/CD44/CD36/IL4R/FAS/JUN/PIM1/STAT3/CD38/IL18R1/ITGB3/IL2RA/TGFB1/HMOX1/EBI3/TNFRSF12A/PTPN11/LEPR/PF4/SOCS3/A2M/CBL/SOCS1 24
HALLMARK_HEDGEHOG_SIGNALING HALLMARK_HEDGEHOG_SIGNALING 12/591 28/3686 0.000657564199328802 0.00292914961519194 0.00188774411290565 CELSR1/HEY1/NRP2/RASA1/MYH9/SCG2/VEGFA/NRP1/NF1/RTN1/CDK6/OPHN1 12
HALLMARK_HYPOXIA HALLMARK_HYPOXIA 43/591 171/3686 0.00112282816871681 0.00458488168892698 0.0029548109703074 CDKN1A/ANXA2/PPP1R15A/CAVIN1/SLC2A3/PLIN2/GPC1/DDIT4/JUN/CDKN1C/TPST2/HS3ST1/PIM1/SDC4/SERPINE1/BHLHE40/ATF3/P4HA2/DDIT3/CAVIN3/MAFF/AKAP12/DPYSL4/PFKP/MYH9/VEGFA/TNFAIP3/HMOX1/PGF/S100A4/CAV1/PRKCA/ZFP36/ENO2/KLF6/BCAN/ADORA2B/HK1/CHST3/STC2/WSB1/KIF5A/LXN 43
HALLMARK_MYOGENESIS HALLMARK_MYOGENESIS 37/591 144/3686 0.0016271133707773 0.00613296578216058 0.00395250211524849 CDKN1A/PLXNB2/GSN/CD36/PTP4A3/LPIN1/KIFC3/HDAC5/ITGB5/AGRN/ABLIM1/SCHIP1/SPHK1/BHLHE40/MYO1C/NOTCH1/CAMK2B/MEF2D/PTGIS/ITGA7/MYH9/TGFB1/MEF2A/AEBP1/CKB/COL6A2/GJA5/SLC6A8/CLU/EFS/SPARC/EPHB3/STC2/RIT1/EIF4A2/MAPRE3/MEF2C 37
HALLMARK_TGF_BETA_SIGNALING HALLMARK_TGF_BETA_SIGNALING 16/591 52/3686 0.00562991599862585 0.0197047059951905 0.0126990586435169 PPP1R15A/THBS1/ID2/CDKN1C/NOG/SERPINE1/SKIL/RAB31/SMAD3/TGFB1/TGIF1/PMEPA1/SPTBN1/SLC20A1/JUNB/BMPR2 16
HALLMARK_CHOLESTEROL_HOMEOSTASIS HALLMARK_CHOLESTEROL_HOMEOSTASIS 19/591 68/3686 0.00850354167194319 0.0268520471527215 0.0173052935463296 CD9/ANTXR2/GNAI1/TP53INP1/ACTG1/ATF3/HMGCS1/LDLR/S100A11/PLSCR1/STARD4/CXCL16/TNFRSF12A/FDFT1/TM7SF2/AVPR1A/CLU/JAG1/HSD17B7 19
HALLMARK_ANGIOGENESIS HALLMARK_ANGIOGENESIS 10/591 28/3686 0.00876801539680701 0.0268520471527215 0.0173052935463296 TIMP1/PTK2/SPP1/PDGFA/VEGFA/NRP1/S100A4/PF4/VCAN/JAG1 10
HALLMARK_ESTROGEN_RESPONSE_EARLY HALLMARK_ESTROGEN_RESPONSE_EARLY 37/591 164/3686 0.0158652310323544 0.0457291953285509 0.0294710173975624 DLC1/CD44/EGR3/MAST4/PRSS23/FHL2/ABHD2/NRIP1/ENDOD1/ABLIM1/AQP3/KRT8/BHLHE40/CCND1/CELSR1/TMEM164/RPS6KA2/MED13L/RAB31/DHRS2/ELF1/KDM4B/KRT18/GJA1/SLC24A3/FLNB/RET/AR/FDFT1/AFF1/NADSYN1/ESRP2/TTC39A/KCNK5/HR/STC2/TOB1 37
paper_data/HSPC_electroRNA-HSPC_UTelectro-enr-h.all.v7.2.symbols-neg.txt
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ID Description GeneRatio BgRatio pvalue p.adjust qvalue geneID Count
paper_data/HSPC_electroRNA-HSPC_UTelectro-enr-h.all.v7.2.symbols-pos.txt
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ID Description GeneRatio BgRatio pvalue p.adjust qvalue geneID Count
HALLMARK_P53_PATHWAY HALLMARK_P53_PATHWAY 35/87 180/3589 3.3774859389315e-24 1.41854409435123e-22 1.2087844413018e-22 FDXR/ZMAT3/PHLDA3/MDM2/RPS27L/DDB2/AEN/CDKN1A/BAX/XPC/PLXNB2/POLH/SESN1/IER5/DRAM1/GADD45A/PLK2/FAS/SDC1/DGKA/PLK3/TRIAP1/BTG2/CYFIP2/PPM1D/TM7SF3/TNFSF9/EPHA2/CCNG1/RNF19B/NOTCH1/ADA/PTPN14/PIDD1/PTPRE 35
HALLMARK_G2M_CHECKPOINT HALLMARK_G2M_CHECKPOINT 20/87 197/3589 2.19082401163594e-08 4.60073042443547e-07 3.92042191555905e-07 UBE2C/TOP2A/CDC25B/HMMR/KPNA2/TROAP/AURKA/CCNB2/CDC20/KIF2C/NEK2/KIF20B/TPX2/PLK1/TACC3/CENPF/CENPA/SMC4/BUB1/CCNF 20
HALLMARK_E2F_TARGETS HALLMARK_E2F_TARGETS 16/87 200/3589 1.6680101080754e-05 0.000233521415130556 0.000198990679559873 CDKN1A/PPM1D/TOP2A/CDC25B/HMMR/KPNA2/AURKA/NCAPD2/CCNB2/CDC20/KIF2C/CIT/DEPDC1/PLK1/TACC3/SMC4 16
HALLMARK_MITOTIC_SPINDLE HALLMARK_MITOTIC_SPINDLE 15/87 195/3589 5.0660881102393e-05 0.000531939251575127 0.000453281567758254 TOP2A/ARHGEF3/AURKA/CCNB2/KIF2C/NEK2/KIF20B/TPX2/SUN2/PLK1/CKAP5/CENPF/WASF1/SMC4/BUB1 15
HALLMARK_APOPTOSIS HALLMARK_APOPTOSIS 11/87 145/3589 0.000636348368240753 0.00534532629322232 0.00455491463582855 FDXR/CDKN1A/BAX/CD38/GADD45A/FAS/BTG2/TOP2A/CDC25B/GNA15/CCNA1 11
paper_data/HSPC_electroRNA-HSPC_electroRNP-enr-h.all.v7.2.symbols-neg.txt
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ID Description GeneRatio BgRatio pvalue p.adjust qvalue geneID Count
paper_data/HSPC_electroRNA-HSPC_electroRNP-enr-h.all.v7.2.symbols-pos.txt
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ID Description GeneRatio BgRatio pvalue p.adjust qvalue geneID Count
HALLMARK_CHOLESTEROL_HOMEOSTASIS HALLMARK_CHOLESTEROL_HOMEOSTASIS 3/5 56/2734 7.91215470808751e-05 0.000553850829566125 0.0002498575170975 HMGCS1/LSS/MVD 3
HALLMARK_MTORC1_SIGNALING HALLMARK_MTORC1_SIGNALING 3/5 180/2734 0.00254339817245719 0.00890189360360017 0.0040158918512482 PSAT1/HMGCS1/INSIG1 3
HALLMARK_ANDROGEN_RESPONSE HALLMARK_ANDROGEN_RESPONSE 2/5 79/2734 0.00779153349485881 0.0181802448213372 0.00820161420511454 HMGCS1/INSIG1 2
HALLMARK_APICAL_JUNCTION HALLMARK_APICAL_JUNCTION 2/5 104/2734 0.0132950601987862 0.0232663553478759 0.0104961001569365 INSIG1/MVD 2
paper_data/HSPC_electroRNP-HSPC_UT-enr-h.all.v7.2.symbols-neg.txt
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42c6d9d3
ID Description GeneRatio BgRatio pvalue p.adjust qvalue geneID Count
HALLMARK_E2F_TARGETS HALLMARK_E2F_TARGETS 92/649 200/3589 5.64907719636043e-21 2.82453859818022e-19 2.37855881952018e-19 LBR/H2AZ1/TCF19/DLGAP5/ESPL1/LMNB1/STMN1/UBE2S/SSRP1/BIRC5/MYBL2/CENPM/ANP32E/MCM3/ASF1B/TIMELESS/CDKN2C/KIF22/MYC/SPC24/MXD3/SHMT1/UNG/CENPE/RANBP1/CDCA3/NAA38/GINS1/POLD1/HMGB3/HNRNPD/SMC1A/SMC4/CIT/MCM7/HMGB2/PRPS1/TOP2A/TFRC/E2F8/H2AX/NUP205/EZH2/RBBP7/TK1/DDX39A/POP7/NCAPD2/BUB1B/TBRG4/SMC6/KIF4A/CCP110/XRCC6/SPC25/MCM4/MKI67/CCNE1/AURKB/MCM2/SPAG5/MELK/CDCA8/CDKN1B/PRDX4/KIF18B/TRA2B/CTCF/RAN/RACGAP1/NOLC1/USP1/SNRPB/TACC3/CDC25A/DUT/MSH2/LIG1/ILF3/RFC2/LYAR/WEE1/RRM2/POLD3/DNMT1/PSIP1/CDKN3/UBE2T/GSPT1/HELLS/TMPO/DCLRE1B 92
HALLMARK_G2M_CHECKPOINT HALLMARK_G2M_CHECKPOINT 67/649 197/3589 2.5589484839547e-08 6.39737120988675e-07 5.38725996622042e-07 LBR/MARCKS/H2AZ1/TPX2/ESPL1/LMNB1/STMN1/UBE2S/BIRC5/MYBL2/H2AZ2/MCM3/CDKN2C/KIF22/MYC/SFPQ/DTYMK/TFDP1/CCNF/CENPE/AMD1/HMGB3/HNRNPD/SMC1A/SMC4/INCENP/TOP2A/HMGN2/H2AX/KIF11/EZH2/E2F2/NUP50/DDX39A/KIF15/CENPF/KIF4A/KIF23/ATF5/MKI67/AURKB/KPNB1/MCM2/CDKN1B/NCL/KMT5A/TRA2B/RAD54L/CTCF/RACGAP1/UCK2/NOLC1/SLC12A2/TACC3/CDC25A/CBX1/HNRNPU/TOP1/ILF3/CHAF1A/NSD2/SQLE/FBXO5/CDKN3/CDC7/GSPT1/TMPO 67
HALLMARK_MTORC1_SIGNALING HALLMARK_MTORC1_SIGNALING 64/649 196/3589 3.03193412976452e-07 5.05322354960753e-06 4.25534614703792e-06 PHGDH/PSAT1/ELOVL6/INSIG1/SCD/CALR/PGM1/CXCR4/SLC37A4/IDH1/DHCR24/CORO1A/UNG/CCNF/ITGB2/TMEM97/TUBA4A/PPA1/SLC1A5/ADD3/DHFR/TFRC/GPI/NIBAN1/NUP205/PGK1/DDX39A/PIK3R3/FADS2/TES/SDF2L1/CTSC/SHMT2/MCM4/MCM2/TXNRD1/ATP5MC1/SLC9A3R1/TOMM40/HSPA5/GLRX/SC5D/TPI1/HSPA9/ERO1A/EBP/CDC25A/PSME3/PLOD2/PPIA/SLC1A4/DHCR7/HMBS/SQLE/PFKL/GLA/RRM2/LDHA/GSR/G6PD/RPN1/ACACA/CYB5B/IMMT 64
HALLMARK_HEME_METABOLISM HALLMARK_HEME_METABOLISM 53/649 187/3589 0.000264854871893134 0.00331068589866417 0.00278794601992772 ALAD/KLF1/TENT5C/PC/TRIM58/FECH/EPB41/TFDP2/AHSP/EPOR/PRDX2/BLVRB/BCAM/BNIP3L/SELENBP1/ALAS2/KLF3/NNT/KEL/NFE2/TFRC/GYPC/H4C3/GLRX5/NARF/MARCHF8/SLC25A38/RNF123/FN3K/E2F2/GYPE/PIGQ/CTSB/DCAF11/ABCG2/CAT/TAL1/HBQ1/ALDH6A1/PPOX/TOP1/LAMP2/ACP5/SLC66A2/HMBS/GDE1/ADD1/SLC25A37/BPGM/NFE2L1/HEBP1/FBXO9/EIF2AK1 53
HALLMARK_OXIDATIVE_PHOSPHORYLATION HALLMARK_OXIDATIVE_PHOSPHORYLATION 53/649 199/3589 0.00134666606237845 0.0134666606237845 0.0113403457884501 IDH2/MRPS15/SLC25A5/GOT2/IDH1/MPC1/COX11/ACADSB/AIFM1/ATP1B1/NNT/NDUFV1/ACAA1/HADHA/GPI/UQCRC1/DLAT/ACAT1/PMPCA/MRPL11/ETFDH/TIMM50/ETFA/CYB5A/ECI1/ATP5MC1/ECH1/NDUFS3/NDUFA3/OAT/TIMM13/FH/UQCRQ/HSPA9/COX6A1/NDUFA2/ALDH6A1/MDH2/POLR2F/IDH3B/CS/ATP5F1A/PRDX3/NDUFS8/LDHA/CYC1/NDUFS7/ECHS1/RHOT2/MRPS12/HSD17B10/IMMT/ATP5MC3 53
HALLMARK_MYC_TARGETS_V1 HALLMARK_MYC_TARGETS_V1 52/649 200/3589 0.00263951115395349 0.0219959262829458 0.0185228852909017 H2AZ1/HNRNPA2B1/TUFM/GOT2/MYC/PPM1G/TFDP1/RANBP1/POLE3/HNRNPD/MCM7/CDK2/RUVBL2/PGK1/FBL/STARD7/XRCC6/PSMA7/C1QBP/MCM4/RRM1/NHP2/KPNB1/MCM2/HNRNPA3/SNRPA/PSMB3/PRDX4/TXNL4A/TRA2B/RAN/YWHAQ/NOLC1/USP1/PRPF31/CCT5/DHX15/PHB/DUT/SNRPA1/HNRNPU/PPIA/PRDX3/LDHA/PABPC4/CYC1/SET/SERBP1/XPOT/PCBP1/GSPT1/SRSF7 52
HALLMARK_FATTY_ACID_METABOLISM HALLMARK_FATTY_ACID_METABOLISM 37/649 134/3589 0.00365430340329994 0.0261021671664281 0.0219807723506763 ALAD/ALDH1A1/H2AZ1/ACSS1/ACSM3/GLUL/IDH1/DHCR24/HADH/ECI2/ACAA1/BPHL/HSD17B4/ALDH9A1/PSME1/ACADS/HPGD/GCDH/ETFDH/ERP29/NCAPH2/CPT2/ACAT2/ECI1/KMT5A/ECH1/FASN/FH/YWHAH/MDH2/IDH3B/LDHA/ECHS1/BCKDHB/HSD17B10/NTHL1/SMS 37
HALLMARK_ADIPOGENESIS HALLMARK_ADIPOGENESIS 46/649 178/3589 0.00519207162512459 0.0324504476570287 0.0273266927638136 ELOVL6/TALDO1/TST/PGM1/PTGER3/CDKN2C/IDH1/RTN3/AIFM1/HADH/APOE/SLC1A5/SLC25A10/UQCRC1/ACADS/DLAT/SLC5A6/MYLK/SLC19A1/CPT2/DHRS7/PDCD4/ECH1/NDUFS3/CAT/UCK1/COQ9/CHCHD10/UQCRQ/COX6A1/ITSN1/MDH2/SLC25A1/CS/DHCR7/AGPAT3/PRDX3/PFKL/CYC1/MIGA2/ECHS1/PREB/ESRRA/COQ3/IMMT/ATP1B3 46
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